Gummadi Yaswanta K, Sutherland Ashley E, Ikeda Kristin M, Connors Lori, Chen Luke Y C
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Division of Clinical Dermatology and Cutaneous Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Br J Haematol. 2025 Jun 22;207(2):619-23. doi: 10.1111/bjh.20221.
Lamotrigine and other anti-seizure medications have been reported to cause both haemophagocytic lympho-histiocytosis (HLH) and drug-induced hypersensitivity syndrome (DIHS). HLH and DIHS have many characteristic clinical, laboratory, pathological findings and underlying mechanisms; we identified significant clinical overlap between these two syndromes in our systematic review. Of note, the presence of haemophagocytosis on bone marrow biopsy, while supportive, is not exclusive to or synonymous with a diagnosis of HLH.
据报道，拉莫三嗪和其他抗癫痫药物可导致噬血细胞性淋巴组织细胞增生症（HLH）和药物性超敏反应综合征（DIHS）。HLH和DIHS有许多特征性的临床、实验室、病理表现及潜在机制；在我们的系统评价中，我们发现这两种综合征之间存在显著的临床重叠。值得注意的是，骨髓活检发现噬血细胞现象虽有支持作用，但并非HLH诊断所特有或等同于HLH诊断。
