中枢神经系统中胆碱能-多巴胺能相互作用的生化研究。

A biochemical study of cholinergic-dopaminergic interactions in the central nervous system.

作者信息

De Souza H, Palermo-Neto J

出版信息

Gen Pharmacol. 1985;16(5):533-6. doi: 10.1016/0306-3623(85)90019-9.

Abstract

The effects of cholinergic (Ach) and anti-Ach drugs on striatal dopamine (DA) levels and turnover were studied. Treatment with both atropine sulfate and scopolamine hydrobromide increased striatal DA levels; scopolamine increased striatal DA turnover and decreased both striatal 3,4-dihydroxyphenylacetic acid (DOPAC) levels and DOPAC/homovanillic acid (HVA) relation. Oxotremorine decreased striatal DA levels but did not change striatal DA turnover or DA metabolites. Changes in striatal DA levels or turnover were not observed after atropine methyl nitrate or physostigmine. The data show the Ach-DA interactions in the striatum.

摘要

研究了胆碱能（乙酰胆碱）和抗胆碱能药物对纹状体多巴胺（DA）水平及周转率的影响。硫酸阿托品和氢溴酸东莨菪碱治疗均使纹状体DA水平升高；东莨菪碱使纹状体DA周转率升高，并使纹状体3,4-二羟基苯乙酸（DOPAC）水平及DOPAC/高香草酸（HVA）比值降低。氧化震颤素使纹状体DA水平降低，但不改变纹状体DA周转率或DA代谢产物。硝酸甲基阿托品或毒扁豆碱处理后未观察到纹状体DA水平或周转率的变化。这些数据显示了纹状体中乙酰胆碱-多巴胺的相互作用。