Kansal Mansi, Bhide Dhanashree, Mahajan Rashmi S, Madnani Nina, Prabhu S Smitha, Sengupta Sujata, Dewan Krati M, Mamatha P, Chaturvedi Nisha
Kansal ENT and Skin Centre, Patiala, Punjab, India.
Department of Dermatology, KEM Hospital, Manipal, Karnataka, India.
Indian J Sex Transm Dis AIDS. 2025 Jan-Jun;46(1):7-15. doi: 10.4103/ijstd.ijstd_51_25. Epub 2025 Jun 9.
Human papillomavirus (HPV) infection is considered to be the most common sexually transmitted disease among both males and females, with an incidence of 14% in South-East Asia. Cervical cancer is one of the most prevalent types of cancer over the past years and the 3rd main cause of cancer-related mortality among adults. There is consensus that persistent high-risk HPV infection is necessary to cause cervical cancer. Vaccination is the best way to prevent HPV infection. Currently, bivalent, quadrivalent, and nonavalent vaccines are available. In this narrative review, information about different diseases caused by human papillomaviruses, role of HPV vaccines in prevention, and their role in the therapy of recalcitrant warts has been discussed. A systematic search of various databases and search engines such as Medline, PubMed, Embase, Scopus, Cochrane Library, and Science Direct was done. HPV vaccines play a preventive role against the HPV types present in the vaccine. Vaccinating girls and boys before sexual debut is anticipated to maximize disease control. The role of vaccines in older women is under evaluation. The role of HPV vaccines as therapeutic modality in recalcitrant warts has also been explored with encouraging results.
人乳头瘤病毒（HPV）感染被认为是男性和女性中最常见的性传播疾病，在东南亚的发病率为14%。宫颈癌是过去几年中最常见的癌症类型之一，也是成年人癌症相关死亡的第三大主要原因。人们一致认为，持续的高危型HPV感染是导致宫颈癌的必要条件。接种疫苗是预防HPV感染的最佳方法。目前，有二价、四价和九价疫苗可供使用。在这篇叙述性综述中，讨论了人乳头瘤病毒引起的不同疾病的相关信息、HPV疫苗在预防中的作用及其在顽固性疣治疗中的作用。对各种数据库和搜索引擎进行了系统检索，如Medline、PubMed、Embase、Scopus、Cochrane图书馆和科学Direct。HPV疫苗对疫苗中所含的HPV类型具有预防作用。预计在首次性行为前为女孩和男孩接种疫苗可最大限度地控制疾病。疫苗在老年女性中的作用正在评估中。HPV疫苗作为顽固性疣治疗手段的作用也已得到探索，结果令人鼓舞。
