美国硝酸盐使用与结直肠癌患病率之间关系的评估。
Evaluation of the Relationship Between Nitrate Use and the Prevalence of Colorectal Cancers in the United States.
作者信息
Egbuchiem Alex N, Okobi Okelue E, Odutola Oluwadamilola D, Igbenabor Christiana A, Okey-Ndeche Uzoma N, Omotunde Oluwatobiloba, Ayantoyinbo Tosin, Abonyi Obinna C, Oghotuoma Oghenemaro O, Nnabude Ogechukwu H, Nwume Chuka G
机构信息
Public Health Research, College of Public Health, University of Nebraska Medical Center (UNMC), Omaha, USA.
Family Medicine, IMG Research Academy and Consulting LLC, Homestead, USA.
出版信息
Cureus. 2025 May 21;17(5):e84530. doi: 10.7759/cureus.84530. eCollection 2025 May.
Background Exposure to nitrate through contaminated drinking water has been suggested as a potential risk factor for colorectal cancer (CRC). However, ecological evidence across the U.S. states remains limited. This study aims to examine the association between average nitrate concentrations and CRC incidence across 31 U.S. states. Methods An ecological analysis was conducted using data from the Centers for Disease Control and Prevention's (CDC's) Environmental Public Health Tracking Network and United States Cancer Statistics (2017-2021). Simple linear regression and Pearson correlation analyses were performed, stratified by gender. Results No significant associations were observed between nitrate concentrations and CRC incidence in both strata. Correlations were weak and non-significant. Conclusions In our study, state-level nitrate exposure was not significantly linked to CRC incidence. Further individual-level studies are recommended.
背景 通过受污染的饮用水接触硝酸盐被认为是结直肠癌（CRC）的一个潜在风险因素。然而，美国各州的生态学证据仍然有限。本研究旨在检验美国31个州的平均硝酸盐浓度与结直肠癌发病率之间的关联。方法 使用疾病控制与预防中心（CDC）的环境公共卫生追踪网络和美国癌症统计数据（2017 - 2021年）进行生态学分析。进行了简单线性回归和Pearson相关性分析，并按性别分层。结果 在两个分层中，均未观察到硝酸盐浓度与结直肠癌发病率之间存在显著关联。相关性较弱且无统计学意义。结论 在我们的研究中，州级硝酸盐暴露与结直肠癌发病率没有显著关联。建议进一步开展个体水平的研究。
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