Al-Beltagi Mohammed, Saeed Nermin Kamal, Bediwy Adel Salah, Elbeltagi Reem
Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta 31511, Alghrabia, Egypt.
Department of Pediatrics, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama 26671, Bahrain.
World J Exp Med. 2025 Jun 20;15(2):104328. doi: 10.5493/wjem.v15.i2.104328.
BACKGROUND: Malnutrition and epilepsy share a complex bidirectional relationship, with malnutrition serving as a potential risk factor for epilepsy development, while epilepsy, in turn, often exerts profound effects on nutritional status. Nutritional interventions have emerged as a critical adjunctive approach in epilepsy management. AIM: To explore the multifaceted associations between malnutrition and epilepsy, structured into three primary sections: (1) Elucidating the impact of malnutrition as a risk factor for epilepsy onset; (2) Examining the reciprocal influence of epilepsy on nutritional status, and (3) Evaluating diverse nutritional interventions in the management of epilepsy. METHODS: A systematic search was conducted across PubMed, Scopus, and Web of Science databases utilizing defined keywords related to malnutrition, epilepsy, and nutritional interventions. Inclusion criteria encompassed various study types, including clinical trials, animal models, cohort studies, case reports, meta-analyses, systematic reviews, guidelines, editorials, and review articles. Four hundred sixteen pertinent references were identified, with 198 review articles, 153 research studies, 21 case reports, 24 meta-analyses, 14 systematic reviews, 4 guidelines, and 2 editorials meeting the predefined criteria. RESULTS: The review revealed the intricate interplay between malnutrition and epilepsy, highlighting malnutrition as a potential risk factor in epilepsy development and elucidating how epilepsy often leads to nutritional deficiencies. Findings underscored the importance of nutritional interventions in managing epilepsy, showing their impact on seizure frequency, neuronal function, and overall brain health. CONCLUSION: This systematic review emphasizes the bidirectional relationship between malnutrition and epilepsy while emphasizing the critical role of nutritional management in epilepsy treatment. The multifaceted insights underscore the need for a holistic approach to addressing nutritional aspects alongside conventional epilepsy management strategies.
背景：营养不良与癫痫存在复杂的双向关系，营养不良是癫痫发生的潜在风险因素，而癫痫反过来又常常对营养状况产生深远影响。营养干预已成为癫痫管理中的一种关键辅助方法。 目的：探讨营养不良与癫痫之间的多方面关联，分为三个主要部分：（1）阐明营养不良作为癫痫发作风险因素的影响；（2）研究癫痫对营养状况的相互影响；（3）评估癫痫管理中各种营养干预措施。 方法：利用与营养不良、癫痫和营养干预相关的特定关键词，在PubMed、Scopus和Web of Science数据库中进行系统检索。纳入标准包括各种研究类型，如临床试验、动物模型、队列研究、病例报告、荟萃分析、系统评价、指南、社论和综述文章。共识别出416篇相关参考文献，其中198篇综述文章、153项研究、21篇病例报告、24项荟萃分析、14项系统评价、4项指南和2篇社论符合预定义标准。 结果：该综述揭示了营养不良与癫痫之间的复杂相互作用，强调营养不良是癫痫发展的潜在风险因素，并阐明了癫痫如何常常导致营养缺乏。研究结果强调了营养干预在癫痫管理中的重要性，显示了其对癫痫发作频率、神经元功能和整体脑健康的影响。 结论：本系统评价强调了营养不良与癫痫之间的双向关系，同时强调了营养管理在癫痫治疗中的关键作用。多方面的见解强调了在传统癫痫管理策略之外，需要采取整体方法来解决营养问题。
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