Aziz M, Beaton M A, Aziz M A, Opoku-Anane J, Elhadad N
Computer Science, Columbia University, New York, New York, USA.
Biomedical Informatics, Columbia University, New York, NY USA.
NPJ Womens Health. 2025;3(1):36. doi: 10.1038/s44294-025-00086-8. Epub 2025 Jun 18.
In this study, we assessed if women with endometriosis have greater odds than matched controls of receiving an autoimmune diagnosis within two-years of their endometriosis diagnosis. We conducted a retrospective cohort study using two large-scale administrative claims databases (2010-2017), identifying 332,409 patients with endometriosis and 1,220,932 matched controls. Compared to matched controls, patients with endometriosis had an increased risk of being diagnosed with rheumatoid arthritis, Hashimoto's disease, systemic lupus erythematosus, multiple sclerosis, pernicious anemia, Sjogren's syndrome or myositis within two-years of their endometriosis diagnosis. The odds of receiving a diagnosis of at least one of the autoimmune conditions among patients with endometriosis were approximately two times greater than matched controls. Our study is the first to show a significant association between endometriosis and autoimmune conditions within a two-year diagnosis window, adding to growing evidence suggesting a potential link between endometriosis and autoimmunity, warranting investigation into shared mechanisms.
在本研究中，我们评估了子宫内膜异位症女性患者在被诊断为子宫内膜异位症后的两年内，相较于匹配的对照组，获得自身免疫性疾病诊断的几率是否更高。我们使用两个大规模行政索赔数据库（2010 - 2017年）进行了一项回顾性队列研究，识别出332,409例子宫内膜异位症患者和1,220,932例匹配的对照组。与匹配的对照组相比，子宫内膜异位症患者在被诊断为子宫内膜异位症后的两年内，被诊断为类风湿性关节炎、桥本氏病、系统性红斑狼疮、多发性硬化症、恶性贫血、干燥综合征或肌炎的风险增加。子宫内膜异位症患者被诊断出至少一种自身免疫性疾病的几率约为匹配对照组的两倍。我们的研究首次表明，在两年的诊断窗口期内，子宫内膜异位症与自身免疫性疾病之间存在显著关联，这进一步证明了子宫内膜异位症与自身免疫性之间可能存在联系，值得对共同机制进行研究。
