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度普利尤单抗治疗肝移植受者大疱性类天疱疮:一例报告

Dupilumab as a treatment for bullous pemphigoid in a liver transplant recipient: A case report.

作者信息

Rashid Sarah S, Mydlarski P Régine, Jafarian Fatemeh

机构信息

Cumming School of Medicine, University of Calgary, AB, Canada.

Division of Dermatology, Department of Medicine, Cumming School of Medicine, University of Calgary, AB, Canada.

出版信息

SAGE Open Med Case Rep. 2025 Jun 19;13:2050313X251350348. doi: 10.1177/2050313X251350348. eCollection 2025.

Abstract

Bullous pemphigoid is a common subepidermal autoimmune bullous disease that affects the skin and mucous membranes. It is more prevalent in the elderly, often resulting in significant morbidity and mortality. Bullous pemphigoid is rare in solid organ transplant recipients but presents unique challenges due to their underlying immunosuppression, which increases the risks of infection and adverse drug reactions. Herein, we present the first reported case of dupilumab successfully treating bullous pemphigoid in a liver transplant recipient.

摘要

大疱性类天疱疮是一种常见的表皮下自身免疫性大疱性疾病,可累及皮肤和黏膜。该病在老年人中更为常见,常导致显著的发病率和死亡率。大疱性类天疱疮在实体器官移植受者中较为罕见,但由于其潜在的免疫抑制作用,会带来独特的挑战,这增加了感染和药物不良反应的风险。在此,我们报告首例成功使用度普利尤单抗治疗肝移植受者大疱性类天疱疮的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b6/12179448/d6c6059f624a/10.1177_2050313X251350348-fig1.jpg

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