Qun Yang, Meiying Feng, Weiming Yao, Dan He
Department of General Surgery, Jingdezhen Hospital of Traditional Chinese Medicine, Jingdezhen, Jiangxi, China.
Department of General Surgery and Clinical Nutrition, Jingdezhen Hospital of Traditional Chinese Medicine, Jingdezhen, Jiangxi, China.
Wideochir Inne Tech Maloinwazyjne. 2025 Jan 15;20(1):36-43. doi: 10.20452/wiitm.2025.17929. eCollection 2025 Apr 9.
The prevalence and risk factors of portal vein thrombosis (PVT) are largely unclear, with an increasing number of studies reporting inconsistent results.
The current study aimed to evaluate the prevalence and risk factors of PVT following hepatectomy through a systematic review and meta‑analysis.
A comprehensive literature search was conducted across multiple databases (PubMed, Embase, and the Cochrane Library) to identify relevant studies. Prospective and retrospective studies reporting on PVT following hepatectomy were included. The Newcastle‑Ottawa Scale (NOS) was used to assess study quality, and the random effects model was used to analyze the prevalence and risk factors.
A total of 15 studies involving 5145 patients were included in the current meta‑analysis. The pooled prevalence of PVT following hepatectomy was 9% (95% CI, 7%-12%) with substantial heterogeneity (I2 = 93.1%). Subgroup analyses showed that a prospective design and larger sample size were associated with lower prevalence rates. PVT prevalence was higher among the patients undergoing simultaneous splenectomy and hepatectomy. Liver cirrhosis (odds ratio [OR], 5.18; 95% CI, 1.85-14.47), portal vein resection (OR, 5.07; 95% CI, 2.2-11.66), and right‑sided hepatectomy (OR, 6.26; 95% CI, 1.8-21.76) were significant risk factors for PVT.
PVT is a notable complication following hepatectomy, with an overall prevalence of 9%. Specific factors that significantly increase the risk of PVT include liver cirrhosis, portal vein resection, and right‑sided hepatectomy.
门静脉血栓形成（PVT）的患病率和危险因素在很大程度上尚不清楚，越来越多的研究报告结果不一致。
本研究旨在通过系统评价和荟萃分析评估肝切除术后PVT的患病率和危险因素。
在多个数据库（PubMed、Embase和Cochrane图书馆）中进行全面的文献检索，以确定相关研究。纳入报告肝切除术后PVT的前瞻性和回顾性研究。采用纽卡斯尔-渥太华量表（NOS）评估研究质量，采用随机效应模型分析患病率和危险因素。
本荟萃分析共纳入15项研究，涉及5145例患者。肝切除术后PVT的合并患病率为9%（95%CI，7%-12%），存在显著异质性（I2 = 93.1%）。亚组分析表明，前瞻性设计和更大的样本量与较低的患病率相关。同时行脾切除术和肝切除术的患者中PVT患病率较高。肝硬化（优势比[OR]，5.18；95%CI，1.85-14.47）、门静脉切除（OR，5.07；95%CI，2.2-11.66）和右半肝切除术（OR，6.26；95%CI，1.8-21.76）是PVT的显著危险因素。
PVT是肝切除术后的一种显著并发症，总体患病率为9%。显著增加PVT风险的特定因素包括肝硬化、门静脉切除和右半肝切除术。
