泪液乳铁蛋白、溶菌酶、白蛋白水平与阻塞性睡眠呼吸暂停综合征之间的关联：一项横断面研究。
Association between tear lactoferrin, lysozyme, albumin levels, and obstructive sleep apnea syndrome: a cross-sectional study.
作者信息
Wang Bin, Hong Chaoyang, Li Wenwei
机构信息
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Department of Ophthalmology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
出版信息
Front Med (Lausanne). 2025 Jun 6;12:1584473. doi: 10.3389/fmed.2025.1584473. eCollection 2025.
BACKGROUND
Obstructive Sleep Apnea Syndrome (OSAS) is associated with various ocular diseases, but its relationship with tear biomarkers for dry eye remains unclear. This study aimed to investigate these tear biomarkers and their correlation with OSAS.
METHODS
This cross-sectional study was conducted at a tertiary hospital in Zhejiang Province from January 2021 to December 2022. Forty-one OSAS patients were enrolled. Tear lactoferrin, lysozyme, and albumin levels (exposure variables) were measured using ELISA, while OSAS (outcome variable) was diagnosed through polysomnography. Age, gender, and BMI were collected as covariates.
RESULTS
Baseline characteristics (including age, gender, and BMI) showed no statistical differences between groups. No significant correlations were found between tear albumin ( = 0.10, > 0.05), lactoferrin ( = 0.18, p > 0.05), lysozyme (r = -0.05, p > 0.05) levels and OSAS.
CONCLUSION
This study found no significant correlation between dry eye tear biomarkers levels and disease severity in OSAS patients. Larger-scale studies are needed to validate these findings.
背景
阻塞性睡眠呼吸暂停综合征（OSAS）与多种眼部疾病相关，但其与干眼症泪液生物标志物的关系尚不清楚。本研究旨在调查这些泪液生物标志物及其与OSAS的相关性。
方法
本横断面研究于2021年1月至2022年12月在浙江省一家三级医院进行。纳入41例OSAS患者。采用酶联免疫吸附测定法（ELISA）检测泪液乳铁蛋白、溶菌酶和白蛋白水平（暴露变量），同时通过多导睡眠图诊断OSAS（结果变量）。收集年龄、性别和体重指数作为协变量。
结果
各组间基线特征（包括年龄、性别和体重指数）无统计学差异。泪液白蛋白（r = 0.10，p > 0.05）、乳铁蛋白（r = 0.18，p > 0.05）、溶菌酶（r = -0.05，p > 0.05）水平与OSAS之间均未发现显著相关性。
结论
本研究发现OSAS患者干眼泪液生物标志物水平与疾病严重程度之间无显著相关性。需要更大规模的研究来验证这些发现。
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