Ko Stephanie Q, Low Shi Yun, Sevdalis Nick
Department of Medicine, National University Hospital, Singapore, Singapore.
Behavioural and Implementation Science Interventions (BISI), National University of Singapore, Singapore, Singapore.
Front Health Serv. 2025 Jun 6;5:1571090. doi: 10.3389/frhs.2025.1571090. eCollection 2025.
Hospital-at-Home interventions have been shown to be clinically and cost-effective, and many healthcare systems internationally are investing in scaling-up such interventions. However, most existing studies focus on how effective the intervention is, rather than how to successfully scale it up. We report a study protocol for a theory-driven investigation of a Hospital-at-Home intervention. We propose a novel combination of two established implementation science frameworks-the EPIS framework and the Scale-Up framework-and apply it to a planned scale-up of a Hospital-at-Home intervention in Singapore.
and analysis: This will be an observational cohort study across 23 months (May 2022 to April 2024) to evaluate the association of outer and inner contextual factors on key implementation outcomes-the volume of patients admitted, operational efficiency and levels of adoption. Statistical process control graphs will be used to examine variation in the implementation outcomes over time. Linear regression will be applied to assess associations of outcomes with contextual factors that are continuous variables; logistic regression will be applied to assess the associations of outcomes with binary/descriptive contextual factors. To supplement these, qualitative methods will be applied using a content analysis of monthly meeting minutes and focus group discussions with the implementation team to understand and explain the outcomes of the observational cohort study.
This protocol has been reviewed and approved by the National Health Group Domain Specific Review Board: Reference Number: 2023/00245. Apart from the end-of-study focus group discussions, waiver of informed consent was sought as the data sources were a review of routinely collected retrospective data. The results of this study will be disseminated to peer-reviewed journals, presented at conferences and shared with policy-level stakeholders.
居家医院干预已被证明在临床和成本效益方面具有优势,国际上许多医疗系统都在投资扩大此类干预措施。然而,大多数现有研究关注的是干预措施的有效性,而非如何成功扩大规模。我们报告了一项针对居家医院干预的理论驱动型调查的研究方案。我们提出了两种既定实施科学框架——EPIS框架和扩大规模框架的新颖组合,并将其应用于新加坡一项计划中的居家医院干预措施的扩大规模。
这将是一项为期23个月(2022年5月至2024年4月)的观察性队列研究,以评估外部和内部背景因素与关键实施结果——入院患者数量、运营效率和采用水平之间的关联。统计过程控制图将用于检查实施结果随时间的变化。线性回归将用于评估结果与作为连续变量的背景因素之间的关联;逻辑回归将用于评估结果与二元/描述性背景因素之间的关联。作为补充,将采用定性方法,对月度会议记录进行内容分析,并与实施团队进行焦点小组讨论,以理解和解释观察性队列研究的结果。
本方案已由国家卫生集团特定领域审查委员会审查并批准:参考编号:2023/00245。除了研究结束时的焦点小组讨论外,由于数据来源是对常规收集的回顾性数据的审查,因此寻求豁免知情同意。本研究结果将发表在同行评审期刊上,在会议上展示,并与政策层面的利益相关者分享。