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膳食生物活性化合物在缓解炎症性肠病相关结直肠癌中的作用

The Roles of Dietary Bioactive Compounds in Alleviating Inflammatory Bowel Disease-Associated Colorectal Cancer.

作者信息

Zhao Jin-Wei, Zhao Wei-Yi, Yu Zhong-Yang

机构信息

Department of Hepatopancreatobiliary Surgery of Second Hospital of Jilin University Jilin University Changchun China.

YanBian Hospital Yanbian University Yanji Jilin Province China.

出版信息

Food Sci Nutr. 2025 Jun 20;13(6):e70432. doi: 10.1002/fsn3.70432. eCollection 2025 Jun.

DOI:10.1002/fsn3.70432
PMID:40548181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12179676/
Abstract

Inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) is a serious global health issue. Owing to the successful mimicking of the entire process of CRC induced by IBD, azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colitis-associated cancer (CAC) animal models have been widely used to study the carcinogenic mechanisms of IBD-associated CRC and aid in the discovery of new candidate target drugs for CRC treatment. This article summarizes the molecular characteristics and mechanisms of the AOM/DSS-induced CAC animal model and reports the effects and mechanisms of dietary active ingredients such as phenolics, flavonoids, terpenes, polysaccharides, alkaloids, and other food extracts in the prevention and treatment of AOM/DSS-induced CAC in preclinical trials. Further research and application of dietary active ingredients against AOM/DSS-induced CAC are needed in the future. In conclusion, this study may provide insights into the potential application of active dietary ingredients in the treatment of CAC.

摘要

炎症性肠病（IBD）相关的结直肠癌（CRC）是一个严重的全球健康问题。由于成功模拟了IBD诱导的CRC的整个过程，氧化偶氮甲烷（AOM）和葡聚糖硫酸钠（DSS）诱导的结肠炎相关癌（CAC）动物模型已被广泛用于研究IBD相关CRC的致癌机制，并有助于发现用于CRC治疗的新候选靶标药物。本文总结了AOM/DSS诱导的CAC动物模型的分子特征和机制，并报告了酚类、黄酮类、萜类、多糖、生物碱等膳食活性成分以及其他食物提取物在临床前试验中预防和治疗AOM/DSS诱导的CAC的作用及机制。未来需要对膳食活性成分抗AOM/DSS诱导的CAC进行进一步研究和应用。总之，本研究可能为活性膳食成分在CAC治疗中的潜在应用提供见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b9b/12179676/30a5cea47839/FSN3-13-e70432-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b9b/12179676/f340a55c7e73/FSN3-13-e70432-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b9b/12179676/f340a55c7e73/FSN3-13-e70432-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b9b/12179676/ca32d50d9404/FSN3-13-e70432-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b9b/12179676/ab8df768e6e2/FSN3-13-e70432-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b9b/12179676/d185375fe246/FSN3-13-e70432-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b9b/12179676/30a5cea47839/FSN3-13-e70432-g002.jpg

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本文引用的文献

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Mol Cancer. 2024 Sep 13;23(1):196. doi: 10.1186/s12943-024-02108-6.
2
Chemopreventive Effects of Polysaccharides and Flavonoids from Okra Flowers in Azomethane/Dextran Sulfate Sodium-Induced Murine Colitis-Associated Cancer.在偶氮甲烷/葡聚糖硫酸钠诱导的小鼠结肠炎相关癌症中，蕹菜花多糖和类黄酮的化学预防作用。
Nutrients. 2023 Nov 17;15(22):4820. doi: 10.3390/nu15224820.
3
Murine models of colorectal cancer: the azoxymethane (AOM)/dextran sulfate sodium (DSS) model of colitis-associated cancer.
结直肠癌的鼠类模型：葡聚糖硫酸钠（DSS）/氧化偶氮甲烷（AOM）诱导的结肠炎相关结肠癌模型。
PeerJ. 2023 Oct 31;11:e16159. doi: 10.7717/peerj.16159. eCollection 2023.
4
Role of Dietary Defatted Rice Bran in the Modulation of Gut Microbiota in AOM/DSS-Induced Colitis-Associated Colorectal Cancer Rat Model.饲用脱脂米糠在 AOM/DSS 诱导的结肠炎相关结直肠癌大鼠模型中对肠道微生物群的调节作用。
Nutrients. 2023 Mar 22;15(6):1528. doi: 10.3390/nu15061528.
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Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis.人参皂苷 Rb1 抑制 AOM/DSS 诱导的结肠癌变。
Anticancer Agents Med Chem. 2023;23(9):1067-1073. doi: 10.2174/1871520623666230119092735.
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