Yamazaki J
Hokkaido Igaku Zasshi. 1985 Jul;60(4):544-54.
Collagen analysis of articular cartilage and subchondral bone was performed on femoral heads obtained from patients of late stage of aseptic necrosis (ANF) (4 cases), and osteoarthritis (OA) (7 cases). In articular cartilage of both diseases, there was not observed any difference in the solubility of collagen compared with normal articular cartilage. However, collagen contents determined by hydroxyproline analysis showed a decrease in both diseases; this tendency was prominent in OA. On the other hand, copper contents showed an increase in ANF while there was a decrease in OA; the fact may suggest that lysyl oxidase acts actively on the formation of a precursor of cross-links in collagen matrix of articular cartilage in ANF. In subchondral bone of both diseases, collagen contents showed an increase in OA, and a decrease in ANF compared with normal subchondral bone. However the solubility of collagen has increased in both diseases. Moreover, lysine hydroxylation and copper contents showed an increase in both OA and ANF; these findings suggest that repairing reaction of the pathological lesion by proliferation of undifferentiated tissue remained even in late stage of the disease. In this paper, the author also discussed about the connective tissue metabolism of these two diseases by determination the types of collagen molecules of pathological cartilage and bone.
对4例无菌性坏死（ANF）晚期患者和7例骨关节炎（OA）患者的股骨头进行关节软骨和软骨下骨的胶原分析。在这两种疾病的关节软骨中，与正常关节软骨相比，未观察到胶原溶解性有任何差异。然而，通过羟脯氨酸分析测定的胶原含量在这两种疾病中均显示降低；这种趋势在OA中更为显著。另一方面，ANF中铜含量增加，而OA中铜含量降低；这一事实可能表明赖氨酰氧化酶在ANF关节软骨胶原基质中交联前体的形成过程中发挥了积极作用。在这两种疾病的软骨下骨中，与正常软骨下骨相比，OA中胶原含量增加，ANF中胶原含量降低。然而，两种疾病中胶原的溶解性均增加。此外，OA和ANF中赖氨酸羟化和铜含量均增加；这些发现表明，即使在疾病晚期，未分化组织的增殖对病理损伤的修复反应仍然存在。在本文中，作者还通过测定病理软骨和骨的胶原分子类型，探讨了这两种疾病的结缔组织代谢。
