Shakeel Sajid, Khan Taqi T, Ahmad Nadeem, Khan Naveed, Iqbal Qaiser, Hassan Muneeb, Asnath Lajward, Shah Abdullah
From the Division of Transplant Surgery, Department of Nephrology and Transplantation, Rehman Medical Institute, Peshawar, Pakistan.
Exp Clin Transplant. 2025 May;23(5):342-346. doi: 10.6002/ect.2025.0045.
Transplant is increasingly recognized as a better alternative to dialysis for patients with endstage renal disease, with living donor transplants generally showing better outcomes. Despite insights into the influence of various donor and recipient factors, the role of donor sex in transplant outcomes remains underexplored. We evaluated recipient outcomes of female donor kidneys compared with outcomes of male donor kidneys in living donor kidney transplant.
We conducted a retrospective analytic cohort study involving 250 patients 18 years and older who underwent living donor kidney transplant. All transplants were performed between related individuals (up to fourth degree). Participants were categorized based on donor-recipient sex combinations, and outcome measures included immediate graft function, delayed graft function, slow graft function, rejection rates, and post-transplant serum creatinine trends.We used Kaplan-Meier survival curves to assess graft and patient survival. We used statistical software for data analysis, incorporating chi-square tests, t tests, analysis of variance, Cox proportional hazards modeling, and log-rank tests.
Among the 250 transplants analyzed, donor demographics revealed near equality in male and female donors (124 female vs 126 male donors), with a significant majority of male recipients (n = 213). The study found no significant differences between male and female donors concerning graft function and post-transplant serum creatinine levels. However, male recipients consistently exhibited higher serum creatinine levels versus female recipients. Although graft and patient survival rates did not differ significantly across sex combinations,female recipients demonstrated consistently better outcomes.
Our study indicated that female donors do not negatively affect immediate graft function or short-term outcomes in living donor kidney transplants.
对于终末期肾病患者，移植越来越被认为是比透析更好的选择，活体供肾移植通常显示出更好的结果。尽管对各种供体和受体因素的影响已有深入了解，但供体性别在移植结果中的作用仍未得到充分探索。我们评估了活体供肾移植中女性供肾与男性供肾受体的结果。
我们进行了一项回顾性分析队列研究，纳入了250名18岁及以上接受活体供肾移植的患者。所有移植均在亲属之间进行（亲缘关系最远为四代）。参与者根据供受体性别组合进行分类，结果指标包括即刻移植肾功能、移植肾功能延迟、移植肾功能缓慢、排斥率以及移植后血清肌酐变化趋势。我们使用Kaplan-Meier生存曲线评估移植肾和患者的生存率。我们使用统计软件进行数据分析，包括卡方检验、t检验、方差分析、Cox比例风险模型和对数秩检验。
在分析的250例移植中，供体人口统计学显示男性和女性供体数量接近相等（124名女性供体对126名男性供体），男性受体占绝大多数（n = 213）。研究发现男性和女性供体在移植肾功能和移植后血清肌酐水平方面没有显著差异。然而，男性受体的血清肌酐水平始终高于女性受体。尽管不同性别组合的移植肾和患者生存率没有显著差异，但女性受体的结果始终更好。
我们的研究表明，女性供体不会对活体供肾移植的即刻移植肾功能或短期结果产生负面影响。
