Clark J T, Kalra P S
Horm Behav. 1985 Sep;19(3):304-10. doi: 10.1016/0018-506x(85)90029-7.
The effects of severe hyperprolactinemia induced by MtTW15 tumors (prolactin- and growth-hormone-secreting pituitary adenoma) on penile reflex activity and blood hormones were examined. There was no significant adverse effect of hyperprolactinemia on penile reflexes at 7, 14, or 21 days after tumor inoculation. However, a virtual elimination of penile reflex activity was observed 34 days after inoculation. Additionally, significant decrements in serum testosterone and dihydrotestosterone and an elevation in progesterone were seen at this time concomittant with greatly increased prolactin levels. The results suggest that erectile dysfunction may contribute to hyperprolactinemia-induced copulatory failure.
研究了由MtTW15肿瘤（分泌催乳素和生长激素的垂体腺瘤）诱导的严重高催乳素血症对阴茎反射活动和血液激素的影响。在接种肿瘤后7、14或21天，高催乳素血症对阴茎反射没有显著不良影响。然而，在接种后34天观察到阴茎反射活动几乎完全消失。此外，此时血清睾酮和双氢睾酮显著降低，孕酮升高，同时催乳素水平大幅升高。结果表明，勃起功能障碍可能导致高催乳素血症引起的交配失败。
