用于肿瘤治疗的纳米酶的合理设计——一种观点

Rational Design of Nanozymes for Tumor Therapy─A Perspective.

作者信息

Zhong Huihai, Nie Kexuan, Zheng Manman, Wang Yujie, Nie Guohui, Zhang Bin

机构信息

Department of Otolaryngology, Shenzhen Key Laboratory of Nanozymes and Translational Cancer Research, Shenzhen Institute of Translational Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518035, China.

Duke Kunshan University, No. 8 Duke Avenue, Kunshan, Jiangsu Province 215316, China.

出版信息

ACS Appl Mater Interfaces. 2025 Jul 2;17(26):37353-37361. doi: 10.1021/acsami.5c08400. Epub 2025 Jun 23.

DOI:10.1021/acsami.5c08400

PMID:40548669

Abstract

Nanozymes are nanomaterials with enzyme-like activities and have become a research hotspot in tumor therapy due to their exceptional properties. However, biological application of nanozymes remains a methodology and safety issue. More systematic and rational design of nanozymes is needed for better tumor treatment. In this Perspective, we focus on the key questions that need to be addressed in nanozyme research, including the catalytic mechanism elucidation and the construction of structure-activity relationship, and introduce several promising rational design methods as well as prospect the future development of nanozymes. This Perspective aims to help researchers clarify the rational design of nanozymes in tumor therapy, offering a comprehensive guide in this emerging field.

摘要

纳米酶是具有类酶活性的纳米材料，因其卓越的性能而成为肿瘤治疗领域的研究热点。然而，纳米酶的生物学应用仍然存在方法学和安全性问题。为了更好地治疗肿瘤，需要对纳米酶进行更系统、合理的设计。在这篇综述中，我们聚焦于纳米酶研究中需要解决的关键问题，包括催化机制的阐明和构效关系的构建，并介绍了几种有前景的合理设计方法，同时对纳米酶的未来发展进行了展望。这篇综述旨在帮助研究人员阐明纳米酶在肿瘤治疗中的合理设计，为这一新兴领域提供全面的指导。