糖皮质激素处理后新生大鼠肝脏细胞色素P-450的早熟发育。
Precocious development of cytochrome P-450 in neonatal rat liver after glucocorticoid treatment.
作者信息
Leakey J E, Fouts J R
出版信息
Biochem J. 1979 Jul 15;182(1):233-5. doi: 10.1042/bj1820233.
Abstract
Intraperitoneal injection of neonatal rats with glucocorticoid hormones causes precocious development of hepatic cytochrome P-450. Glucagon injection fails to stimulate this cytochrome P-450 development. Adult liver cytochrome P-450 is less responsive to glucocorticoid stimulation than is that of neonatal rat liver. Adrenalectomy of prematurely delivered neonatal animals prevents the early postnatal development of cytochrome P-450. Glucocorticoids failed to increase cytochrome P-450 concentrations in foetal rat liver. These findings imply that, although glucocorticoids are mandatory regulatory factors controlling cytochrome P-450 development, they are not themselves the 'trigger' initiating onset of that development.
摘要
给新生大鼠腹腔注射糖皮质激素会导致肝细胞色素P - 450早熟。注射胰高血糖素不能刺激这种细胞色素P - 450的发育。成年肝脏细胞色素P - 450对糖皮质激素刺激的反应不如新生大鼠肝脏。对早产新生动物进行肾上腺切除术可阻止细胞色素P - 450在出生后的早期发育。糖皮质激素未能增加胎鼠肝脏中细胞色素P - 450的浓度。这些发现表明，虽然糖皮质激素是控制细胞色素P - 450发育的必需调节因子，但它们本身并不是启动该发育起始的“触发因素”。
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