Zheng Hui, Zhang Mingqi, Xiao Tingting, Zheng Yicen, Cheng Lianfang, Huang Meiling, Zhang Man, Xu Lichun
Nursing Department, Zhongshan Hospital, Xiamen University, Xiamen, 361004, China.
Nursing College, Fujian Medical University, Fuzhou, 350108, China.
Support Care Cancer. 2025 Jun 23;33(7):613. doi: 10.1007/s00520-025-09629-w.
This systematic review aims to identify the factors influencing chemotherapy-induced oral mucositis in cancer patients.
A comprehensive literature search was conducted across PubMed, Web of Science, Embase, The Cochrane Library, VIP, Wanfang, CNKI, CBM, and CINAHL from the establishment of the databases to August 2024. Meta-analysis was performed using RevMan5.4 software, with odds ratios (OR) and 95% confidence intervals (CI) used to assess the risk factors. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS) and the evaluation criteria recommended by the Agency for Healthcare Research and Quality (AHRQ). The quality of evidence was graded using the GRADEpro GDT.
The analysis included 10 studies with a total of 2365 patients. Six studies were of high quality, and four studies were of moderate quality. The results indicated that the following factors were associated with an increased risk of chemotherapy-induced oral mucositis (CIOM) in cancer patients: a history of oral disease, combination chemotherapy, smoking history, oral hygiene, and chemotherapy regimens containing 5-FU/methotrexate.
This meta-analysis identified several potential independent risk factors for CIOM in cancer patients. Early screening and timely intervention for patients with these risk factors are crucial for reducing the likelihood of CIOM and improving overall prognosis.
本系统评价旨在确定影响癌症患者化疗所致口腔黏膜炎的因素。
从数据库建立至2024年8月，在PubMed、Web of Science、Embase、Cochrane图书馆、维普、万方、知网、中国生物医学文献数据库和护理学与健康领域数据库（CINAHL）中进行全面的文献检索。使用RevMan5.4软件进行荟萃分析，采用比值比（OR）和95%置信区间（CI）评估危险因素。使用纽卡斯尔-渥太华量表（NOS）和医疗保健研究与质量局（AHRQ）推荐的评估标准评估方法学质量。使用GRADEpro GDT对证据质量进行分级。
分析纳入10项研究，共2365例患者。6项研究质量高，4项研究质量中等。结果表明，以下因素与癌症患者化疗所致口腔黏膜炎（CIOM）风险增加相关：口腔疾病史、联合化疗、吸烟史、口腔卫生以及含5-氟尿嘧啶/甲氨蝶呤的化疗方案。
本荟萃分析确定了癌症患者CIOM的几个潜在独立危险因素。对具有这些危险因素的患者进行早期筛查和及时干预对于降低CIOM的可能性和改善总体预后至关重要。
