肌浆网Ca2+-ATP酶（SERCA）阻断作为肥胖的一种治疗策略。
SERCA blockade as a treatment strategy for obesity.
作者信息
Al-Naimi Suha, Qaisar Rizwan
机构信息
Department of Basic Medical Sciences, College of Medicine, University of Sharjah, 27272, Sharjah, United Arab Emirates.
School of Health and Science, University of Suffolk, Ipswich, Suffolk, IP4 1QJ, UK.
出版信息
Eur J Appl Physiol. 2025 Jun 23. doi: 10.1007/s00421-025-05852-9.
Sarco/endoplasmic reticulum calcium ATPase (SERCA) pump is essential for maintaining calcium homeostasis in various cell types, including adipocytes. The SERCA function is closely associated with metabolic health, as the dysregulation of SERCA is implicated in the development of obesity. Thus, regulating SERCA may be clinically relevant for treating obesity and related complications. We discuss various pharmacological and genetic tools to regulate SERCA function for treating obesity. Next, we discuss preclinical and clinical data on the therapeutic efficacy of regulating SERCA in obesity. We also discuss sarcolipin, a SERCA-associated inhibitory protein, as a molecular target for regulating SERCA. Lastly, we discuss challenges, clinical implications, and future directions of regulating SERCA for treating obesity.
肌浆网/内质网钙ATP酶（SERCA）泵对于维持包括脂肪细胞在内的多种细胞类型中的钙稳态至关重要。SERCA功能与代谢健康密切相关，因为SERCA失调与肥胖症的发生有关。因此，调节SERCA在治疗肥胖症及相关并发症方面可能具有临床意义。我们讨论了用于调节SERCA功能以治疗肥胖症的各种药理学和遗传学工具。接下来，我们讨论调节SERCA在肥胖症治疗中的疗效的临床前和临床数据。我们还讨论了肌浆网膜蛋白，一种与SERCA相关的抑制蛋白，作为调节SERCA的分子靶点。最后，我们讨论了调节SERCA治疗肥胖症的挑战、临床意义和未来方向。
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