Chandra Tilak, Jaiswal Sarika, Iquebal Mir Asif, Kumar Dinesh
Division of Agricultural Bioinformatics, ICAR-Indian Agricultural Statistics Research Institute, New Delhi, 110012, India.
Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, 248002, India.
Funct Integr Genomics. 2025 Jun 23;25(1):135. doi: 10.1007/s10142-025-01643-9.
A recent study by Sang et al. successfully demonstrated the simultaneous editing of SBEIIb to develop rice germplasm with an enhanced resistant starch composition, without compromising palatability. This research reveals the unique advantages of promoter engineering in optimizing resistant starch content while preserving palatability achieved through precise modulation of starch biosynthetic and regulatory enzymes, outperforming conventional gene editing approaches. Such findings pave the way for developing elite genotypes with the potential to reduce the societal burden of chronic diseases and satiety management.
桑等人最近的一项研究成功证明了对淀粉分支酶IIb（SBEIIb）进行同时编辑，以培育出抗性淀粉成分增强且不影响适口性的水稻种质。这项研究揭示了启动子工程在优化抗性淀粉含量方面的独特优势，同时通过精确调控淀粉生物合成和调节酶来保持适口性，优于传统的基因编辑方法。这些发现为培育具有减轻慢性病社会负担和饱腹感管理潜力的优良基因型铺平了道路。
