Selgas R, Carmona A R, Martinez M E, Perez-Fontan M, Salinas M, Conesa J, Martinez Ara J, Sicilia L S
Int J Artif Organs. 1985 Jul;8(4):181-6.
The transport of solutes across the peritoneum may be increased by the topical administration of nitroprusside; the effects of the drug seem to be due to an increase in the number of perfused capillaries and/or in their permeability. We have compared the peritoneal mass transfer coefficients (MTC) for urea, creatinine and parathormone (PTH) under basal conditions and after administration of nitroprusside (4.5 mg/l dialysate) in 15 patients under CAPD therapy. The mean increments of the MTC were 48.8% for urea, 77.5% for creatinine and 323% for PTH. The relative MTC increments for the three molecules (taken in pairs) were: MTCPTH/urea' 2.53 times (mean), MTCPTH/creatinine' 1.7 times, and MTCcreatinine/urea' 0.73-times, with very variable ranges. The overall mean increment (OMI) for all three ratios ranged from -1.25 and +6 times. In six patients, some of the relative increments (and in three of them the OMI) were negative but the epidemiological features of these patients revealed no clear data. The OMI shows a direct correlation with the body surface area and an inverse correlation with the the duration of CAPD and ESRD and with the number of peritonitis episodes, albeit without statistical significance. We conclude that the peritoneal vascular reserve has individual characteristics, and that perhaps the OMI or some other similar index might serve to quantify and characterise it, if our findings are confirmed.
硝普钠局部给药可增加溶质通过腹膜的转运；该药物的作用似乎是由于灌注毛细血管数量增加和/或其通透性增加。我们比较了15例持续性非卧床腹膜透析（CAPD）治疗患者在基础条件下以及给予硝普钠（4.5mg/l透析液）后尿素、肌酐和甲状旁腺激素（PTH）的腹膜质量转运系数（MTC）。MTC的平均增加值分别为：尿素48.8%，肌酐77.5%，PTH 323%。三种分子（两两相比）的相对MTC增加值为：MTCPTH/尿素为2.53倍（均值），MTCPTH/肌酐为1.7倍，MTC肌酐/尿素为0.73倍，范围变化很大。所有三个比值的总体平均增加值（OMI）在-1.25至+6倍之间。在6例患者中，一些相对增加值（其中3例的OMI）为负值，但这些患者的流行病学特征未显示明确数据。OMI与体表面积呈正相关，与CAPD和终末期肾病（ESRD）的病程以及腹膜炎发作次数呈负相关，尽管无统计学意义。我们得出结论，腹膜血管储备具有个体特征，如果我们的发现得到证实，那么也许OMI或其他类似指标可能有助于对其进行量化和表征。
