Samtleben W, Schmidt B, Blumenstein M, Gurland H J
Int J Artif Organs. 1985 Jul;8 Suppl 2:33-4.
Blood and plasma processing by membranes was introduced into clinical medicine in 1979. In the meantime, membrane plasma separation (plasmapheresis) has become very satisfactory and is now a routine therapeutic procedure in many apheresis centers. Plasma fractionation by membranes (plasma filtration or cascade filtration) for unselective removal of high molecular weight pathogens from the separated plasma is technically possible but its routine clinical application is still limited to a few diseases with at least IgM-sized target proteins. The separation of IgG from albumin needed to treat many autoimmune diseases requires further development of both the membranes and the filtration technology.
1979年，膜式血液和血浆处理技术被引入临床医学。与此同时，膜式血浆分离术（单采血浆术）已变得非常令人满意，如今在许多单采中心已成为常规治疗程序。通过膜进行血浆分离（血浆过滤或级联过滤）以从分离出的血浆中无选择性地去除高分子量病原体在技术上是可行的，但其常规临床应用仍仅限于少数几种具有至少IgM大小靶蛋白的疾病。治疗许多自身免疫性疾病所需的从白蛋白中分离IgG仍需要膜和过滤技术的进一步发展。
