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来自[植物名称]地上部分的二萜类化合物及其抗肝癌潜力。 （注：原文中“and their anti-hepatocarcinoma potential”前缺少具体植物名称，这里补充了[植物名称]以便完整理解句子意思，实际翻译时应根据准确的原文信息进行）

Diterpenoids from the aerial parts of and their anti-hepatocarcinoma potential.

作者信息

Wu Huanling, Liu Chang, Li Siqin, Zhang Chenchen, Yang Guang, Ma Jiang, Huang Ziying, Wang Shixiong, Xu Yonghao, He Xin, Yang Ji

机构信息

School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University Guangzhou 510006 China

China Academy of Chinese Medical Sciences Beijing 100700 China.

出版信息

RSC Adv. 2025 Jun 23;15(25):20134-20142. doi: 10.1039/d5ra02720a. eCollection 2025 Jun 10.

DOI:10.1039/d5ra02720a
PMID:40551991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12183791/
Abstract

Three new -kaurane diterpenoids, isodosins E-G (1-3), along with 20 known ones (4-23), were obtained from the aerial parts of (Maxim.) Hara. The structures of the new compounds were elucidated using 1D/2D NMR spectra and HREIMS data, and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. The anti-hepatocarcinoma activities of compounds 2, 3, 5, 8, 13, 19, and 23 were evaluated against HepG2 and Huh7 cell lines using the CCK-8 assay. Among them, compounds 3, 8, and 23 exhibited high inhibitory effects on HepG2 cells, with IC values of 6.94 ± 9.10 μM, 71.66 ± 10.81 μM, and 43.26 ± 9.07 μM, respectively. In a Hepa1-6 xenograft mouse model, compound 8 significantly inhibited tumor growth at doses of 50 and 100 mg kg, demonstrating its potent anti-hepatocarcinoma activity.

摘要

从（Maxim.）Hara的地上部分获得了三种新的贝壳杉烷二萜类化合物，异豆素E-G（1-3），以及20种已知化合物（4-23）。利用一维/二维核磁共振光谱和高分辨电喷雾电离质谱数据阐明了新化合物的结构，并通过电子圆二色光谱（ECD）计算确定了它们的绝对构型。使用CCK-8法评估了化合物2、3、5、8、13、19和23对HepG2和Huh7细胞系的抗肝癌活性。其中，化合物3、8和23对HepG2细胞表现出高抑制作用，IC值分别为6.94±9.10μM、71.66±10.81μM和43.26±9.07μM。在Hepa1-6异种移植小鼠模型中，化合物8在50和100mg/kg剂量下显著抑制肿瘤生长，表明其具有强大的抗肝癌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/9b9d2dbbe54f/d5ra02720a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/3a642c7171d7/d5ra02720a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/2b8a10eba8cf/d5ra02720a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/c71a3ee5596d/d5ra02720a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/c560cbfd8240/d5ra02720a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/e93488e0faab/d5ra02720a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/9b9d2dbbe54f/d5ra02720a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/3a642c7171d7/d5ra02720a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/2b8a10eba8cf/d5ra02720a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/c71a3ee5596d/d5ra02720a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/c560cbfd8240/d5ra02720a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/e93488e0faab/d5ra02720a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737c/12183791/9b9d2dbbe54f/d5ra02720a-f6.jpg

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本文引用的文献

[1]
ent-Kaurane diterpenoids from Isodon henryi and their anti-inflammatory activities.

Phytochemistry. 2024-12

[2]
Diterpenoids from the Aerial Parts of with Selective Cytotoxic Activity.

Molecules. 2024-6-8

[3]
Six new diterpenoids with anti-inflammatory and cytotoxic activity from Isodon serra.

Fitoterapia. 2024-7

[4]
Oridonin from : An emerging potential in cancer therapy - A comprehensive review.

Food Sci Nutr. 2024-2-1

[5]
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2024

[6]
The Natural Product Oridonin as an Anticancer Agent: Current Achievements and Problems.

Curr Pharm Biotechnol. 2024

[7]
Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo.

Biochem Pharmacol. 2023-4

[8]
Recent advances in oridonin derivatives with anticancer activity.

Front Chem. 2023-2-9

[9]
Structurally diverse diterpenoids from Isodon oresbius and their bioactivity.

Bioorg Chem. 2022-7

[10]
The diterpenoid adenanthin upregulates the expression of natural killer group 2D receptor ligands in hepatocellular carcinoma cells.

Mol Cell Probes. 2021-10

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