Lee Hye Jun, Kim Jung-Ha
Department of Family Medicine, Chung-Ang University Medical Center, College of Medicine, Chung-Ang University, Seoul, Republic of Korea,
Department of Family Medicine, Chung-Ang University Medical Center, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Gerontology. 2025;71(5):365-375. doi: 10.1159/000545328. Epub 2025 Mar 24.
Remnant cholesterol (RC) is an important contributor to cardiovascular disease development. We aimed to investigate the effect of physical activity (PA) type on serum RC levels in Korean adults.
We used data from the 2016-2021 Korea National Health and Nutrition Examination Survey, and included 32,877 adults. Serum RC was calculated by subtracting the low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels from the total cholesterol level. Hyper-remnant cholesterolemia was defined as a serum RC level of ≥30 mg/dL. PA was classified into aerobic, resistance, and walking exercises, which involved practicing 150 min of moderate, 75 min of high-intensity PA, or a combination of the 2, per week; doing resistance exercise more than 2 days per week; walking more than 150 min per week, respectively. Multivariate logistic regression analysis was performed to examine the association between serum RC and PA type.
Among those aged <65 years, the odds ratio (OR) of hyper-remnant cholesterolemia was 1.23 times higher in the group that did not perform resistance exercise than in the group that performed more than 2 resistance exercises per week (95% confidence interval [CI] 1.12-1.36, p < 0.0001). Among those aged ≥65 years, the OR of hyper-remnant cholesterolemia was 1.31 times higher in the group that did not practice walking exercise than in the group that walked for more than 150 min per week (95% CI: 1.11-1.55, p < 0.01).
This study revealed that resistance exercise in those aged <65 years and walking exercise in those aged ≥65 years were significantly associated with low RC levels in Korean adults.
残余胆固醇（RC）是心血管疾病发展的重要促成因素。我们旨在研究体育活动（PA）类型对韩国成年人血清RC水平的影响。
我们使用了2016 - 2021年韩国国家健康与营养检查调查的数据，纳入了32,877名成年人。血清RC通过从总胆固醇水平中减去低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平来计算。高残余胆固醇血症定义为血清RC水平≥30mg/dL。PA分为有氧运动、抗阻运动和步行运动，分别涉及每周进行150分钟的中等强度运动、75分钟的高强度运动或两者结合；每周进行抗阻运动超过2天；每周步行超过150分钟。进行多变量逻辑回归分析以检验血清RC与PA类型之间的关联。
在年龄<65岁的人群中，未进行抗阻运动的组中高残余胆固醇血症的优势比（OR）比每周进行超过2次抗阻运动的组高1.23倍（95%置信区间[CI] 1.12 - 1.36，p < 0.0001）。在年龄≥65岁的人群中，未进行步行运动的组中高残余胆固醇血症的OR比每周步行超过150分钟的组高1.31倍（95% CI：1.11 - 1.55，p < 0.01）。
本研究表明，年龄<65岁人群的抗阻运动和年龄≥65岁人群的步行运动与韩国成年人低RC水平显著相关。
