Beekhuis W H, McCarey B E
Invest Ophthalmol Vis Sci. 1985 Nov;26(11):1634-6.
A hydrogel intracorneal lens for refractive keratoplasty must have predictable and stable optics when implanted in the corneal stroma. A series of experiments was performed to evaluate the hydrogel hydration stability when in the corneal stromal environment. Hydrogel ICLs of 54%, 63%, 66% and 71% water content showed no loss of hydration (by weight) after one week in the rabbit corneal stroma. In vitro experiments with hydrogel discs of 56%, 65%, 69.5% and 75% water content were subjected to swelling pressures ranging from 55 to 150 mmHg in a suction chamber. Only the hydrogel of 75% water content showed a significant loss of hydration at the physiologic swelling pressure of 55 mmHg. This study shows that hydrogel materials with up to 69.5% water content can be expected to be dimensionally stable when used in keratorefractive surgery.
用于屈光性角膜移植的水凝胶人工角膜透镜植入角膜基质后必须具备可预测且稳定的光学性能。进行了一系列实验以评估水凝胶在角膜基质环境中的水合稳定性。含水量为54%、63%、66%和71%的水凝胶人工角膜透镜在兔角膜基质中放置一周后未出现水合作用丧失（按重量计）的情况。对含水量为56%、65%、69.5%和75%的水凝胶圆盘进行体外实验，使其在抽吸室内承受55至150毫米汞柱的膨胀压力。只有含水量为75%的水凝胶在55毫米汞柱的生理膨胀压力下出现了明显的水合作用丧失。这项研究表明，含水量高达69.5%的水凝胶材料在用于角膜屈光手术时有望保持尺寸稳定。
