Herrera-Restrepo Oscar, Multani Jasjit K, Zhou Zifan, Paltanwale Queenie, Olaiya Tosin, Coutinho Anna D, Shah Rajeev B, Chen Chi-Chang
GSK, Philadelphia, PA, USA.
IQVIA, Falls Church, VA, USA.
Curr Med Res Opin. 2025 Jul 6:1-13. doi: 10.1080/03007995.2025.2522806.
In the United States (US), meningococcal serogroup B (MenB) vaccination is currently recommended under shared clinical decision-making for 16-23-year-olds to prevent invasive meningococcal disease; the MenB vaccine may be co-administered with other vaccines recommended for this age group.
A retrospective analysis of two US health insurance claims databases was conducted to estimate the proportion of commercially insured and Medicaid-insured 16-23-year-olds with potential missed opportunities for MenB vaccine series initiation co-administration. Potential missed opportunities were defined as visits with healthcare providers during which other recommended vaccines (MenACWY, Tdap, HPV, influenza, and/or COVID-19) were administered, but not the initial MenB vaccine dose.
In 2022, 74.5% of commercially insured and 67.1% of Medicaid-insured 16-23-year-olds had potential missed opportunities for MenB vaccination initiation co-administration. The proportion of missed opportunities was higher among 19-23-year-olds (versus 16-18-year-olds) and lower for visits with pediatricians (versus internists or general practitioners/family physicians). The most frequently co-administered vaccine was the MenACWY vaccine.
Many 16-23-year-olds had potential missed opportunities for MenB series initiation co-administration. Increasing awareness of the opportunity to initiate the MenB series co-administration may improve meningococcal vaccination coverage in the US.
在美国，目前建议在共同临床决策下，为16至23岁人群接种B群脑膜炎球菌疫苗（MenB）以预防侵袭性脑膜炎球菌病；MenB疫苗可与该年龄组推荐的其他疫苗同时接种。
对两个美国医疗保险理赔数据库进行回顾性分析，以估计商业保险和医疗补助保险覆盖的16至23岁人群中，MenB疫苗系列起始接种或同时接种可能错失机会的比例。可能错失的机会定义为在与医疗服务提供者就诊期间，接种了其他推荐疫苗（A、C、W、Y群脑膜炎球菌结合疫苗、破伤风类毒素、白喉类毒素和无细胞百日咳疫苗、人乳头瘤病毒疫苗、流感疫苗和/或新冠疫苗），但未接种MenB疫苗首剂。
2022年，74.5%的商业保险覆盖和67.1%的医疗补助保险覆盖的16至23岁人群有MenB疫苗起始接种或同时接种的潜在错失机会。19至23岁人群（相对于16至18岁人群）错失机会的比例更高，而与儿科医生就诊（相对于内科医生或全科医生/家庭医生）时错失机会的比例更低。最常同时接种的疫苗是A、C、W、Y群脑膜炎球菌结合疫苗。
许多16至23岁人群有MenB疫苗系列起始接种或同时接种的潜在错失机会。提高对MenB系列起始接种或同时接种机会的认识，可能会提高美国的脑膜炎球菌疫苗接种覆盖率。
