Qin Yanglin, Wang Wei, Gu Yu, Shi Xuefeng
Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300020, China.
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Neurosci Bull. 2025 Jun 24. doi: 10.1007/s12264-025-01448-7.
The visual cortex is an essential part of the brain for processing visual information. It exhibits structural and functional plasticity, which is crucial for adapting to complex visual environments. The quintessential manifestation of visual cortical plasticity is ocular dominance plasticity during the critical period, which involves numerous cellular and molecular events. While previous studies have emphasized the role of visual cortical neurons and their associated functional molecules in visual plasticity, recent findings have revealed that structural factors such as the extracellular matrix and glia are also involved. Investigating how these molecules interact to form a complex network that facilitates plasticity in the visual cortex is crucial to our understanding of the development of the visual system and the advancement of therapeutic strategies for visual disorders like amblyopia.
视觉皮层是大脑中处理视觉信息的重要部分。它具有结构和功能可塑性，这对于适应复杂的视觉环境至关重要。视觉皮层可塑性的典型表现是关键期内的眼优势可塑性，这涉及众多细胞和分子事件。虽然先前的研究强调了视觉皮层神经元及其相关功能分子在视觉可塑性中的作用，但最近的研究结果表明，细胞外基质和神经胶质等结构因素也参与其中。研究这些分子如何相互作用形成一个促进视觉皮层可塑性的复杂网络，对于我们理解视觉系统的发育以及弱视等视觉障碍治疗策略的进展至关重要。
