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An analysis of the therapeutic efficacy and underlying mechanisms of combining lycopene with dental pulp stem cells to ameliorate alzheimer's disease in rats.

作者信息

Xu Zhiguo, Zhu Yi, Liu Lefeng, Liu Chao, Zhang Zhongshan, Li Minghe, Yao Linhua, Wang Feng, Dong Zhilong, Gao Shaorong, Kang Lan, Shi Lei

机构信息

School of Life Sciences and Technology, Tongji University, Shanghai, China.

Department of Pharmaceutical Engineering, School of Life and Health Sciences, Huzhou College, Huzhou, Zhejiang, China.

出版信息

Metab Brain Dis. 2025 Jun 24;40(6):233. doi: 10.1007/s11011-025-01661-3.

DOI:10.1007/s11011-025-01661-3
PMID:40553395
Abstract
摘要

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An analysis of the therapeutic efficacy and underlying mechanisms of combining lycopene with dental pulp stem cells to ameliorate alzheimer's disease in rats.番茄红素与牙髓干细胞联合改善大鼠阿尔茨海默病的治疗效果及潜在机制分析
Metab Brain Dis. 2025 Jun 24;40(6):233. doi: 10.1007/s11011-025-01661-3.
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本文引用的文献

1
Z-Isomers of lycopene and β-carotene exhibit greater skin-quality improving action than their all-E-isomers.番茄红素和β-胡萝卜素的 Z 异构体比全 E 异构体具有更强的改善皮肤质量的作用。
Food Chem. 2023 Sep 30;421:135954. doi: 10.1016/j.foodchem.2023.135954. Epub 2023 Mar 22.
2
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus.脉络丛将先天免疫与脑积水时的 CSF 失调联系起来。
Cell. 2023 Feb 16;186(4):764-785.e21. doi: 10.1016/j.cell.2023.01.017.
3
Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice.
纹状体ZBTB16与阿尔茨海默病小鼠的认知缺陷有关。
Int Neurourol J. 2022 Nov;26(Suppl 2):S106-116. doi: 10.5213/inj.2244254.127. Epub 2022 Nov 30.
4
Alzheimer's disease: Pathophysiology and dental pulp stem cells therapeutic prospects.阿尔茨海默病：病理生理学与牙髓干细胞治疗前景
Front Cell Dev Biol. 2022 Sep 15;10:999024. doi: 10.3389/fcell.2022.999024. eCollection 2022.
5
Choroid plexus imaging to track neuroinflammation - a translational model for mouse and human studies.脉络丛成像用于追踪神经炎症——一种适用于小鼠和人类研究的转化模型。
Neural Regen Res. 2023 Mar;18(3):521-522. doi: 10.4103/1673-5374.346471.
6
Low Xanthophylls, Retinol, Lycopene, and Tocopherols in Grey and White Matter of Brains with Alzheimer's Disease.阿尔茨海默病患者大脑灰质和白质中的叶黄素、视黄醇、番茄红素和生育酚含量较低。
J Alzheimers Dis. 2023;94(1):1-17. doi: 10.3233/JAD-220460.
7
Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum.脑 MRI 阿尔茨海默病临床谱内脉络丛体积和通透性。
Radiology. 2022 Sep;304(3):635-645. doi: 10.1148/radiol.212400. Epub 2022 May 17.
8
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease.神经炎症和突触功能障碍中的微生物群：以阿尔茨海默病为例。
Mol Neurodegener. 2022 Mar 5;17(1):19. doi: 10.1186/s13024-022-00522-2.
9
Potential role of dental pulp stem cells conditioned medium for odontoblastic differentiation.牙髓干细胞条件培养基在成牙本质细胞分化中的潜在作用。
Biol Res. 2022 Mar 4;55(1):11. doi: 10.1186/s40659-022-00380-8.
10
The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling.烟酰胺单核苷酸和番茄红素通过 Keap1-Nrf2 信号通路预防 D-半乳糖诱导衰老模型中的认知障碍和氧化损伤。
Gene. 2022 May 15;822:146348. doi: 10.1016/j.gene.2022.146348. Epub 2022 Feb 17.