Wang Dong, Guan Haoran
College of Integrative Medicine of Tianjin University of traditional Chinese Medicine, Tianjin 301617, China; Graduate School of Tianjin University of traditional Chinese Medicine, Tianjin 301617, China; First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China.
Graduate School of Tianjin University of traditional Chinese Medicine, Tianjin 301617, China; First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China.
Cell Signal. 2025 Oct;134:111940. doi: 10.1016/j.cellsig.2025.111940. Epub 2025 Jun 18.
Macrophages serve as sentinels on the front line of tissue defense, acting as essential components of the body's arsenal against invading pathogens. Their metabolic modes and functions are closely linked to the progression and regression of diseases. Typically, macrophages preferentially utilize the glycolytic pathway for energy production, with glycolysis being particularly dominant in hypoxic environments. Notably, tumor-associated macrophages (TAMs) also rely on glycolysis for energy production even in the presence of sufficient oxygen, a phenomenon known as the classic "Warburg effect." TAMs play a critical role in the development and progression of malignant tumors, including angiogenesis, and are considered a key component of the tumor microenvironment (TME). They promote tumor growth, invasion, metastasis, and tumor neoangiogenesis. The infiltration level and polarization status of TAMs within the tumor stroma are closely associated with patient prognosis and represent potential targets for tumor immunotherapy. Furthermore, tumor growth is heavily dependent on tumor neoangiogenesis. In this paper, we systematically reviewed the literature on macrophages and tumor therapy to elucidate and summarize the relationship between the glycometabolic mechanisms of macrophage polarization and tumors. This review aims to provide theoretical guidance for tumor treatment and the development of antitumor drugs.
巨噬细胞是组织防御前线的哨兵，是机体抵御入侵病原体武器库的重要组成部分。它们的代谢模式和功能与疾病的进展和消退密切相关。通常情况下，巨噬细胞优先利用糖酵解途径产生能量，在缺氧环境中糖酵解尤为占主导。值得注意的是，肿瘤相关巨噬细胞（TAM）即使在有充足氧气的情况下也依赖糖酵解产生能量，这一现象被称为经典的“瓦伯格效应”。TAM在恶性肿瘤的发生和发展中起关键作用，包括血管生成，被认为是肿瘤微环境（TME）的关键组成部分。它们促进肿瘤生长、侵袭、转移和肿瘤新生血管形成。肿瘤基质中TAM的浸润水平和极化状态与患者预后密切相关，是肿瘤免疫治疗的潜在靶点。此外，肿瘤生长严重依赖肿瘤新生血管形成。在本文中，我们系统回顾了关于巨噬细胞与肿瘤治疗的文献，以阐明和总结巨噬细胞极化的糖代谢机制与肿瘤之间的关系。本综述旨在为肿瘤治疗和抗肿瘤药物的开发提供理论指导。
