累及颅底的鼻咽腺样囊性癌：一例报告并文献复习
Nasopharyngeal adenoid cystic carcinoma with skull base involvement: A case-report and review of the literature.
作者信息
Sbai Achraf Amine, Es-Sahli Fatima Zahra, Belfadil Drissia, Tsen Adil Abdenbi, Lachkar Azeddine, Elayoubi Fahd
机构信息
Department of Ear Nose and Throat, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco; Laboratory of Oto-Neuro-Ophtalmology, Faculty of Medicine and Pharmacy of Oujda, Mohammed the First University, Morocco.
Department of Ear Nose and Throat, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco.
出版信息
Int J Surg Case Rep. 2025 Aug;133:111497. doi: 10.1016/j.ijscr.2025.111497. Epub 2025 Jun 19.
INTRODUCTION AND IMPORTANCE
Adenoid cystic carcinomas (ACC) arising from minor salivary glands is rare, comprising only 10-20 % of all ACC cases. Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare tumor, accounting for <5 % of head and neck adenoid cystic carcinomas.
PRESENTATION OF CASE
We report the case of a 68-year-old man, complained from headache with bilateral nasal obstruction and deterioration of the general state, nasal endoscopy and sinonasal imaging revealed a locally advanced NACC infiltrating the skull base.
CLINICAL DISCUSSION
Treatment for these tumors generally based on radiation, as radical surgical resection is generally difficult and carries significant morbidity.
CONCLUSION
NACC is a rare disease that causes significant morbidity when it invades the base of the skull. Complete surgical resection is the main treatment for ACC, and may be combined with radiotherapy.
引言与重要性
起源于小唾液腺的腺样囊性癌（ACC）较为罕见，仅占所有ACC病例的10%-20%。鼻咽腺样囊性癌（NACC）是一种罕见肿瘤，占头颈部腺样囊性癌的比例不到5%。
病例介绍
我们报告一例68岁男性病例，患者因头痛伴双侧鼻塞及全身状况恶化就诊，鼻内镜检查和鼻窦成像显示为局部晚期NACC，侵犯颅底。
临床讨论
这些肿瘤的治疗通常基于放疗，因为根治性手术切除通常困难且会带来显著的发病率。
结论
NACC是一种罕见疾病，侵犯颅底时会导致显著的发病率。完整的手术切除是ACC的主要治疗方法，可联合放疗。
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