Peters Loraine Hl, Joore Manuela A, Gidding-Slok Annerika Hm, Keijsers Lotte Cem, Twellaar Mascha, Boudewijns Esther A, van Schayck Onno Cp, Muris Jean Wm, Kimman Merel L
Department of Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands
Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands.
BMJ Open. 2025 Jun 24;15(6):e099762. doi: 10.1136/bmjopen-2025-099762.
The increasing prevalence of chronic conditions and multimorbidity places a significant burden on patients and leads to increasing challenges for healthcare systems, especially in primary care. Recognising the multifaceted nature of chronic conditions, the Assessment of Burden of Chronic Conditions (ABCC) tool was developed to support person-centred care, by facilitating shared decision-making and self-management. This study aims to evaluate the cost-effectiveness of the ABCC tool in primary care.
This cost-effectiveness analysis was conducted over 18 months alongside a clustered, two-arm quasi-experimental study in primary care in the Netherlands.
The study included 231 participants diagnosed with chronic obstructive pulmonary disease (COPD), asthma, type 2 diabetes mellitus (T2DM) and/or chronic heart failure (CHF). Of these, 173 were assigned to the intervention group and 58 to the control group.
The intervention group was intended to incorporate the ABCC tool into routine consultations, while the control group had to continue care as usual.
Outcomes were assessed from a societal perspective, including quality-adjusted life years (QALYs) derived via the EuroQol-5D-5L (EQ-5D-5L) questionnaire. Costs were measured using adapted versions of the Productivity Costs Questionnaire (PCQ) and Medical Consumption Questionnaire (MCQ). Sensitivity analyses (SAs) included a healthcare perspective, per-protocol analysis (to account for disruptions caused by COVID-19) and exclusion of home care costs (to address extreme outliers). Moreover, all analyses were performed for well-being-adjusted life years (WALYs), derived from the ICEpop CAPability measure for Adults (ICECAP-A) questionnaire.
The ABCC tool was more expensive and effective than usual care, with an incremental cost-effectiveness ratio (ICER) of €64 525 per QALY and a 29% probability of cost-effectiveness. With the exception of the healthcare perspective, the SAs yielded more favourable outcomes in terms of cost-effectiveness, with ICERs (probability of cost-effectiveness) of €41 484 (31%), €8683 (58%) and €23 905 (48%) for a healthcare perspective, per-protocol analysis and exclusion of home care costs, respectively. Outcomes for QALY and WALY were comparable.
While the primary analysis suggested a relatively low probability of cost-effectiveness, the SAs showed higher probabilities. The per-protocol analysis suggested that the ABCC tool can be cost-effective when actually used.
NCT04127383.
慢性病和多重疾病的患病率不断上升,给患者带来了沉重负担,也给医疗系统带来了越来越多的挑战,尤其是在初级保健领域。认识到慢性病的多方面性质,开发了慢性病负担评估(ABCC)工具,以通过促进共同决策和自我管理来支持以患者为中心的护理。本研究旨在评估ABCC工具在初级保健中的成本效益。
这项成本效益分析与荷兰初级保健领域的一项整群、双臂准实验研究同时进行,为期18个月。
该研究纳入了231名被诊断患有慢性阻塞性肺疾病(COPD)、哮喘、2型糖尿病(T2DM)和/或慢性心力衰竭(CHF)的参与者。其中,173人被分配到干预组,58人被分配到对照组。
干预组旨在将ABCC工具纳入常规会诊,而对照组则继续照常护理。
从社会角度评估结局,包括通过欧洲五维度健康量表(EQ-5D-5L)问卷得出的质量调整生命年(QALYs)。使用生产力成本问卷(PCQ)和医疗消费问卷(MCQ)的改编版本来衡量成本。敏感性分析(SAs)包括医疗保健角度、符合方案分析(以考虑COVID-19造成的干扰)以及排除家庭护理成本(以处理极端异常值)。此外,所有分析均针对从成人ICEpop能力量表(ICECAP-A)问卷得出的幸福感调整生命年(WALYs)进行。
ABCC工具比常规护理更昂贵但更有效,每获得一个QALY的增量成本效益比(ICER)为64,525欧元,成本效益概率为29%。除医疗保健角度外,敏感性分析在成本效益方面产生了更有利的结果,从医疗保健角度、符合方案分析和排除家庭护理成本得出的ICER(成本效益概率)分别为41,484欧元(31%)、8683欧元(58%)和23,905欧元(48%)。QALY和WALY的结果具有可比性。
虽然初步分析表明成本效益概率相对较低,但敏感性分析显示概率更高。符合方案分析表明,ABCC工具在实际使用时可能具有成本效益。
NCT04127383。