Yingchoncharoen Pitchaporn, Chaisrimaneepan Nattanicha, Paz Miriam, Hoffman Alexandra, Lohano Kuldeep, Labib Safaa, Pixley John
Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, USA.
Department of Pathology, Texas Tech University Health Science Center, Lubbock, Texas, USA.
J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251350580. doi: 10.1177/23247096251350580. Epub 2025 Jun 25.
Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is characterized by high fever, lymph node swelling, and leukopenia. It is usually a benign self-limited disease. However, there are reports that it can be associated with other conditions, including infectious and noninfectious processes, autoimmune diseases such as systemic lupus erythematosus (SLE), or even life-threatening conditions like macrophage activation syndrome (MAS). Here, we report 2 cases of Kikuchi disease with non-self-limited disease in West Texas. The first case involves a 13-year-old Hispanic female who presented with prolonged fever for 8 weeks, cervical lymphadenopathy, and malaise. A year later, she was diagnosed with SLE. The second case is a 36-year-old Hispanic female who presented with prolonged fever and cervical, supraclavicular, axillary lymphadenopathy, and pancytopenia. She then developed MAS or hemophagocytic lymphohistiocytosis.
菊池-藤本病，又称组织细胞坏死性淋巴结炎，其特征为高热、淋巴结肿大和白细胞减少。它通常是一种良性自限性疾病。然而，有报道称它可能与其他病症相关，包括感染性和非感染性过程、自身免疫性疾病如系统性红斑狼疮（SLE），甚至像巨噬细胞活化综合征（MAS）这样危及生命的病症。在此，我们报告2例西得克萨斯州非自限性菊池病病例。首例病例为一名13岁西班牙裔女性，出现持续8周的发热、颈部淋巴结病和不适。一年后，她被诊断为系统性红斑狼疮。第二例病例是一名36岁西班牙裔女性，出现持续发热以及颈部、锁骨上、腋窝淋巴结病和全血细胞减少。随后她发展为巨噬细胞活化综合征或噬血细胞性淋巴组织细胞增生症。
