Jung Hyun Joo, Lee Il Jae, Yoon Seung-Hyun
Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Gyeonggi-do, South Korea.
Department of Plastic Surgery, Ajou University Hospital, Ajou University School of Medicine, Suwon, Gyeonggi-do, South Korea.
Risk Manag Healthc Policy. 2020 Sep 22;13:1687-1693. doi: 10.2147/RMHP.S271283. eCollection 2020.
Kikuchi disease (KD) is typically a benign disease. Recent studies reporting recurrence or serious cases suggest a possible association of KD with systemic autoimmune disorders. We performed a long-term analysis of the characteristics of KD in patients of all ages and assessed KD recurrence or progress to systemic autoimmune disorders.
Electronic medical records of patients diagnosed with KD between April 1995 and May 2017 were reviewed for clinical and laboratory manifestations.
In total, 480 patients were confirmed to have KD based on histopathology findings. The mean age at KD diagnosis was 24.4 years. Recurrence occurred in 11.3% of patients; 2.7% developed autoimmune diseases after KD diagnosis. Patients who experienced recurrence had more extranodal symptoms, lymphopenia, and a longer lymphopenia-recovery duration. Patients who developed autoimmune diseases after KD were more likely to have extranodal symptoms, KD recurrence, and anti-nuclear antibody positivity.
KD patients with risk factors need to be followed-up for KD recurrence and the development of systemic autoimmune diseases.
菊池病（KD）通常是一种良性疾病。近期有关复发或严重病例的研究提示KD可能与全身性自身免疫性疾病相关。我们对各年龄段KD患者的特征进行了长期分析，并评估了KD复发或进展为全身性自身免疫性疾病的情况。
回顾了1995年4月至2017年5月期间诊断为KD的患者的电子病历，以了解其临床和实验室表现。
根据组织病理学结果，共有480例患者确诊为KD。KD诊断时的平均年龄为24.4岁。11.3%的患者出现复发；2.7%的患者在KD诊断后发生自身免疫性疾病。经历复发的患者有更多结外症状、淋巴细胞减少以及更长的淋巴细胞减少恢复持续时间。KD后发生自身免疫性疾病的患者更可能有结外症状、KD复发以及抗核抗体阳性。
具有危险因素的KD患者需要随访观察KD复发及全身性自身免疫性疾病的发生情况。
