Schreiber Yoko, Villalobos Armelle Perez Cortes, McEachern James, Walkty Andrew
Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Department of Medical Microbiology & Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
J Assoc Med Microbiol Infect Dis Can. 2024 Oct 25;9(3):188-195. doi: 10.3138/jammi-2023-0040. eCollection 2024 Oct.
is a gram-positive bacterium that is considered a member of the normal human oral flora. Serious infections due to this organism are rare, with only eight case reports of endocarditis due to published worldwide in the English language literature.
We report the case of a previously healthy 43-year-old man who presented with multiple acute subarachnoid hemorrhages secondary to cerebral mycotic aneurysms after several weeks of weight loss and headache, and we summarize previously published cases of endocarditis due to .
Blood cultures yielded filamentous gram-positive bacilli identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry as . The patient was treated with antimicrobial therapy (initially aqueous penicillin G, then ceftriaxone) for 12 weeks with a good clinical response. Endocarditis was suspected but not definitively proven on echocardiography. There was no clear odontogenic source of infection.
This report of cerebral mycotic aneurysms secondary to possible endocarditis highlights the potential pathogenic nature of infection, and supports the use of MALDI-TOF in rapid identification of uncommon bacterial pathogens.
是一种革兰氏阳性菌，被认为是人类正常口腔菌群的成员。由该菌引起的严重感染较为罕见，英文文献中全球仅发表了8例因感染导致的心内膜炎病例报告。
我们报告了一例既往健康的43岁男性病例，该患者在经历数周体重减轻和头痛后，因脑真菌性动脉瘤出现多处急性蛛网膜下腔出血，并且我们总结了既往发表的因感染导致的心内膜炎病例。
血培养产生丝状革兰氏阳性杆菌，通过基质辅助激光解吸/电离飞行时间（MALDI-TOF）质谱鉴定为。患者接受了12周的抗菌治疗（最初为水剂青霉素G，然后是头孢曲松），临床反应良好。怀疑有心内膜炎，但超声心动图未明确证实。没有明确的牙源性感染源。
这份关于可能的心内膜炎继发脑真菌性动脉瘤的报告突出了感染的潜在致病性质，并支持使用MALDI-TOF快速鉴定罕见细菌病原体。
