HLA DRB1*等位基因与红斑狼疮、类风湿关节炎及其他伴有皮肤受累的自身免疫性疾病
HLA DRB1* Allele Lupus Erythematosus, Rheumatoid Arthritis, and other Autoimmune Disorders with Skin Involvement.
作者信息
Klimi Eleni
机构信息
Department of Dermatology, Thriassio General Hospital, Elefsina, Greece.
出版信息
Mediterr J Rheumatol. 2025 Mar 30;36(1):8-11. doi: 10.31138/mjr.111024.oad. eCollection 2025 Mar.
OBJECTIVE
A narrative short review has been made aiming to identify the most important immune disorders associated with the HLA DRB1*allele.
MATERIAL AND METHODS
Data have been taken from PubMed, and 36 articles have been retrieved.
RESULTS
It has been found that DRB116:02 is associated with autoimmune diseases with production of autoantibodies, mainly systemic lupus erythematosus and myasthenia gravis. DRB104 is associated with lupus erythematosus, bullous pemphigoid, and pemphigus vulgaris. DRB1is also associated with dermatitis herpetiformis, alopecia areata, acute generalised exanthematous pustulosis, and systemic sclerosis. No association of DRB1 has been found either with psoriasis or with psoriatic arthritis, while the association of Cw6 and DRB107 confers less severe joint damage in patients with psoriatic arthritis.
CONCLUSION
DRB1* is associated with lupus erythematosus rheumatoid arthritis and with most immune disorders with skin involvement.
目的
进行一篇叙述性简短综述，旨在确定与HLA DRB1*等位基因相关的最重要的免疫紊乱。
材料与方法
数据取自PubMed，检索到36篇文章。
结果
发现DRB116:02与产生自身抗体的自身免疫性疾病相关，主要是系统性红斑狼疮和重症肌无力。DRB104与红斑狼疮、大疱性类天疱疮和寻常型天疱疮相关。DRB1还与疱疹样皮炎、斑秃、急性泛发性脓疱病和系统性硬化症相关。未发现DRB1与银屑病或银屑病关节炎有关，而Cw6和DRB107的关联使银屑病关节炎患者的关节损伤较轻。
结论
DRB1*与红斑狼疮、类风湿性关节炎以及大多数累及皮肤的免疫紊乱有关。
Zotero 插件