Tabatabaei Seyed Ali, Masoumi Ahmad, Mirzaei Arash, Mirshahi Reza, Momenaei Bita, Bijani Faezeh Moghimpour, Rashidinia Ali, Nazari Mohammadreza, Ahadifard Mohammad, Mahdizad Zahra, Habeel Samer, Baharnoori Seyed Mahbod, Soleimani Mohammad
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Eye Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
J Curr Ophthalmol. 2025 Jun 5;36(3):284-290. doi: 10.4103/joco.joco_67_24. eCollection 2024 Jul-Sep.
To describe the demographic characteristics, etiology, microbiological spectrum, and antibiotic sensitivity patterns in patients with endophthalmitis.
This is a retrospective case series spanning from May 2012 to September 2018. All included patients were diagnosed with endophthalmitis and confirmed by laboratory tests. Data were collected on patient demographics, types of endophthalmitis, and microbiologic and medical records.
Nine hundred ninety-two records of patients with endophthalmitis were assessed. Of the total cases, 657 patients (66.2%) were male, whereas 335 (33.8%) were female. The mean age of the patients was 57.2 ± 22.8 years and ranged from 2 to 95 years. The type of endophthalmitis was acute postcataract surgery (44.4%), posttraumatic (26.7%), chronic postcataract surgery (6.6%), endogenous (6.4%), postintravitreal injection (5.0%), keratitis-associated (3.6%), postvitrectomy (2.7%), bleb-associated (2.4%), postkeratoplasty (1.9%), and device-related (0.1%). The most frequently isolated organisms were (11.7%), followed by (5.2%) and (5.1%). Antibiotic susceptibility testing in patients with acute postcataract surgery endophthalmitis showed variable sensitivity of isolates to vancomycin (81.4%), ciprofloxacin (76.2%), and levofloxacin (75.0%). In patients with posttraumatic endophthalmitis, high rates of zone 1 injury (61.5%), traumatic cataract (67.9%), and intraocular foreign body (IOFB) (29.8%) were observed.
is the most common causative pathogen in patients with endophthalmitis, its increasing resistance to vancomycin and fluoroquinolones may pose some challenges to the treatment of endophthalmitis in the future. Regarding the presence of IOFB, zone 1 injury, and traumatic cataracts that might be associated with an increased risk of posttraumatic endophthalmitis, it is better to consider these aspects in penetrating eye injuries.
描述眼内炎患者的人口统计学特征、病因、微生物谱及抗生素敏感性模式。
这是一项回顾性病例系列研究，时间跨度为2012年5月至2018年9月。所有纳入患者均被诊断为眼内炎且经实验室检查确诊。收集了患者的人口统计学数据、眼内炎类型以及微生物学和病历资料。
对992例眼内炎患者的记录进行了评估。在所有病例中，657例患者（66.2%）为男性，335例（33.8%）为女性。患者的平均年龄为57.2±22.8岁，年龄范围为2至95岁。眼内炎类型为急性白内障术后（44.4%）、外伤后（26.7%）、慢性白内障术后（6.6%）、内源性（6.4%）、玻璃体内注射后（5.0%）、角膜炎相关性（3.6%）、玻璃体切除术后（2.7%）、滤过泡相关性（2.4%）、角膜移植术后（1.9%）以及装置相关性（0.1%）。最常分离出的微生物是[具体微生物1]（11.7%），其次是[具体微生物2]（5.2%）和[具体微生物3]（5.1%）。急性白内障术后眼内炎患者的抗生素敏感性测试显示，[具体微生物]分离株对万古霉素的敏感性为81.4%，对环丙沙星为76.2%，对左氧氟沙星为75.0%。在外伤后眼内炎患者中，观察到1区损伤发生率较高（61.5%）、外伤性白内障发生率较高（67.9%）以及眼内异物（IOFB）发生率较高（29.8%）。
[具体微生物]是眼内炎患者最常见的致病病原体，其对万古霉素和氟喹诺酮类药物的耐药性增加可能给未来眼内炎的治疗带来一些挑战。关于可能与外伤后眼内炎风险增加相关的眼内异物、1区损伤和外伤性白内障的存在，在穿透性眼外伤中最好考虑这些因素。
