Larney Conor, Foley Peter, Wu Jason, Daniel Benjamin S
Department of Dermatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
Skin Health Institute, Carlton, Victoria, Australia.
Australas J Dermatol. 2025 Sep;66(6):e324-e334. doi: 10.1111/ajd.14557. Epub 2025 Jun 25.
Real-world use of dupilumab has unveiled a spectrum of side effects that were not fully appreciated in initial clinical trials. While dupilumab remains a highly effective treatment for atopic dermatitis, clinicians must be aware of real-world adverse effects including ocular complications, inflammatory arthritis, psoriasiform eruptions and head and neck dermatitis; as well as reported associations including cutaneous T-cell lymphoma, alopecia areata, vitiligo and weight gain.
度普利尤单抗在现实世界中的应用揭示了一系列在最初临床试验中未被充分认识到的副作用。虽然度普利尤单抗仍然是治疗特应性皮炎的高效药物，但临床医生必须了解现实世界中的不良反应，包括眼部并发症、炎性关节炎、银屑病样皮疹和头颈部皮炎；以及已报道的关联，包括皮肤T细胞淋巴瘤、斑秃、白癜风和体重增加。
