Lin Chao-Ruei, Liu Ya-Fen, Huang I-Ching, Chen Yi-Jen, Chen Chia-Hsin, Lin Ko-Long
Department of Physical Medicine and Rehabilitation, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.
Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Gangshan Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.
J Cardiovasc Dev Dis. 2025 May 28;12(6):204. doi: 10.3390/jcdd12060204.
In the past, an isolated ventricular septal defect (VSD) was categorized as a simple lesion with assumed negligible long-term risks when treated correctly in childhood; however, evidence has suggested that patients with isolated congenital VSDs carry a substantial burden of cardiovascular morbidity throughout life. This study aimed to investigate the cardiopulmonary function (CPF) in isolated VSD patients of a young age and the relationship of CPF with age, sex and body mass index (BMI). This retrospective cohort study was conducted at a tertiary medical center in southern Taiwan. We recruited children and adolescents (aged 5 to 18 years) with isolated VSDs who underwent the symptom-limited treadmill exercise test. Data from 289 children and adolescents (157 males, 132 females) were included in the analysis. The participants were stratified into three groups according to age. The male patients had a significantly higher oxygen uptake at the anaerobic threshold (AT VO) and a higher peak oxygen uptake (peak VO) (all < 0.05). Normalized AT VO (mL/kg/min) and normalized peak VO (mL/kg/min) were significantly negatively associated with BMI. In conclusion, male patients with isolated VSDs had similar or better CPF compared with female patients. BMI had a negative association with CPF in young VSD patients.
过去，孤立性室间隔缺损（VSD）被归类为一种简单病变，假定在儿童期得到正确治疗时长期风险可忽略不计；然而，有证据表明，孤立性先天性VSD患者一生中心血管疾病负担较重。本研究旨在调查年轻孤立性VSD患者的心肺功能（CPF）以及CPF与年龄、性别和体重指数（BMI）的关系。这项回顾性队列研究在台湾南部的一家三级医疗中心进行。我们招募了接受症状限制平板运动试验的孤立性VSD儿童和青少年（5至18岁）。分析纳入了289名儿童和青少年（157名男性，132名女性）的数据。参与者根据年龄分为三组。男性患者在无氧阈（AT VO）时的摄氧量显著更高，峰值摄氧量（peak VO）也更高（均P<0.05）。标准化AT VO（mL/kg/min）和标准化peak VO（mL/kg/min）与BMI显著负相关。总之，孤立性VSD男性患者的CPF与女性患者相似或更好。BMI与年轻VSD患者的CPF呈负相关。
