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家蚕血影蛋白家族基因的特征及其在驯化和育种中的进化作用

Characterization of Spectrin Family Genes and Their Evolutionary Roles in Domestication and Breeding of the Silkworm .

作者信息

Lu Kunpeng, Zhan Chengyu, Shen Jianghong, Zhi Chao, Deng Jun, Lai Kerui, Han Minjin, Hu Hai, Tong Xiaoling, Dai Fangyin

机构信息

State Key Laboratory of Resource Insects, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.

出版信息

Insects. 2025 May 24;16(6):556. doi: 10.3390/insects16060556.

DOI:10.3390/insects16060556
PMID:40558986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12193018/
Abstract

The spectrin family genes play critical roles in cytoskeletal organization and cellular integrity, yet their evolutionary and functional significance in non-classical model organisms remains poorly explored. Here, we systematically identified and characterized spectrin family genes in the silkworm . Genome-wide analysis identified 17 predicted spectrin genes, which were integrated into eight optimized members through transcriptome-guided structural refinement. Multi-species genomic analysis revealed 8, 23, and 24 spectrin family genes in , , and , respectively. Phylogenetic analysis revealed conserved clades across insects and mammals, with gene family expansions in vertebrates. Spatiotemporal expression profiling demonstrated ubiquitous expression of these genes during silkworm development. Population genomic analyses detected strong selection signatures in during domestication and implicated as a candidate gene for silk yield enhancement in Chinese-improved strains (CHN-I). Expression profiles of parental strains and F offspring from a commercial hybrid cross (Jingsong × Haoyue) revealed expression correlating with heterosis in silk yield traits. This study elucidates the characterization and functional relevance of silkworm spectrin genes, providing insights into their roles in domestication and breeding.

摘要

血影蛋白家族基因在细胞骨架组织和细胞完整性中发挥着关键作用，然而它们在非经典模式生物中的进化和功能意义仍未得到充分探索。在此，我们系统地鉴定并表征了家蚕中的血影蛋白家族基因。全基因组分析鉴定出17个预测的血影蛋白基因，通过转录组引导的结构优化将其整合为8个优化成员。多物种基因组分析分别在果蝇、小鼠和人类中揭示了8个、23个和24个血影蛋白家族基因。系统发育分析揭示了昆虫和哺乳动物中保守的进化枝，脊椎动物中存在基因家族扩张。时空表达谱显示这些基因在家蚕发育过程中普遍表达。群体基因组分析在驯化过程中检测到家蚕的强烈选择信号，并暗示某一基因是中国改良品系（CHN-I）中提高蚕丝产量的候选基因。来自商业杂交组合（菁松×皓月）的亲本菌株和F1代子代的表达谱显示某一基因的表达与蚕丝产量性状的杂种优势相关。本研究阐明了家蚕血影蛋白基因的特征和功能相关性，为其在驯化和育种中的作用提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/9e6690007d9f/insects-16-00556-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/26acced56bc1/insects-16-00556-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/cae3a543c466/insects-16-00556-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/9bca36fdd788/insects-16-00556-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/9e6690007d9f/insects-16-00556-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/26acced56bc1/insects-16-00556-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/a9fdcc723cbb/insects-16-00556-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/8c701c23af14/insects-16-00556-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/15b129d212f3/insects-16-00556-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/cae3a543c466/insects-16-00556-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/9bca36fdd788/insects-16-00556-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/3bed61441da5/insects-16-00556-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78e8/12193018/9e6690007d9f/insects-16-00556-g008.jpg

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本文引用的文献

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SilkMeta: a comprehensive platform for sharing and exploiting pan-genomic and multi-omic silkworm data.丝科元：一个用于共享和利用全基因组和多组学家蚕数据的综合平台。
Nucleic Acids Res. 2024 Jan 5;52(D1):D1024-D1032. doi: 10.1093/nar/gkad956.
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Spectrins: molecular organizers and targets of neurological disorders. spectrins：神经疾病的分子组织者和靶点。
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Nucleic Acids Res. 2023 Jan 6;51(D1):D384-D388. doi: 10.1093/nar/gkac1096.
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High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecological adaptation.高分辨率家蚕泛基因组为人工选择和生态适应提供了遗传见解。
Nat Commun. 2022 Sep 24;13(1):5619. doi: 10.1038/s41467-022-33366-x.
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Comprehensive silk gland multi-omics comparison illuminates two alternative mechanisms in silkworm heterosis.综合丝腺多组学比较揭示了家蚕杂种优势的两种替代机制。
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SilkBase: an integrated transcriptomic and genomic database for Bombyx mori and related species.丝基数据库：家蚕及其相关物种的转录组和基因组综合数据库。
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Diversity of Dystrophin Gene Mutations and Disease Progression in a Contemporary Cohort of Duchenne Muscular Dystrophy.当代杜氏肌营养不良队列中肌营养不良蛋白基因突变的多样性与疾病进展
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