Song Xingya, Lyu Yingxian, Zhang Yuqiao, Ding Wenjia, Huang Yongzhen, Yang Shang
Henan Academy of Sericulture Science, Zhengzhou, Henan, China.
College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.
Front Genet. 2025 Jun 10;16:1580806. doi: 10.3389/fgene.2025.1580806. eCollection 2025.
The silkworm (), has been farmed in China for over 5,000 years, and holds significant economic value. Recent genomic advances have deepened our understanding of silk production mechanisms, enabling the development of improved silkworm breeds. Further research is needed to identify effective molecular markers linked to silk production traits, as this will enhance genetic improvement efforts.
In the genome-wide association analysis study, we identified 40 significant single nucleotide polymorphisms (SNPs) and 28 candidate genes which were related to cocoon shell weight, cocoon width and whole cocoon weight in four silkworm strains in Henan. Through linkage imbalance block analysis, we found that the (ATPase inhibitor-like protein) and (OTU domain-containing protein 7B) were strongly selected. By using online databases, we found that the gene was highly expressed in the posterior silk glands and may play an important role in the process of silk production.
The candidate genes in this study may affect the production and health traits of silkworms, and may provide an important reference for silkworm breeding.
家蚕在中国已养殖了5000多年，具有重要的经济价值。最近的基因组进展加深了我们对蚕丝生产机制的理解，有助于培育改良家蚕品种。需要进一步研究以鉴定与蚕丝生产性状相关的有效分子标记，因为这将加强遗传改良工作。
在全基因组关联分析研究中，我们在河南的四个家蚕品系中鉴定出40个与茧层重量、茧宽和全茧重量相关的显著单核苷酸多态性（SNP）和28个候选基因。通过连锁不平衡块分析，我们发现（ATP酶抑制剂样蛋白）和（含OTU结构域蛋白7B）受到强烈选择。通过使用在线数据库，我们发现该基因在后丝腺中高度表达，可能在蚕丝生产过程中起重要作用。
本研究中的候选基因可能影响家蚕的生产和健康性状，可能为家蚕育种提供重要参考。
