Yaroshenko Mariia, Christoff Monika, Ścibiorski Mateusz, Surowiec Karolina, Jakubowicz-Gil Joanna, Sumorek-Wiadro Joanna
Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland.
Department of Functional Anatomy and Cytobiology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
NeuroSci. 2025 Jun 5;6(2):52. doi: 10.3390/neurosci6020052.
Gliomas are the most common central nervous system tumors and account for 30% of all primary brain tumors, 80% of all malignant ones, and the vast majority of deaths that are caused by brain tumors. Among them, glioblastoma multiforme has the most aggressive and invasive course. Due to its heterogeneity, it is difficult to treat, and one of the reasons for this are glioma stem cells (GSCs). Therapies such as radiotherapy and chemotherapy are used to treat gliomas but do not bring the expected results. Therefore, treatments targeting glioma stem cells are emerging. A promising strategy is to target GSCs with natural compounds. This review aims to describe the problem of glioma stem cells, the treatment of gliomas, and therapies based on natural compounds, which are promising for the future.
神经胶质瘤是最常见的中枢神经系统肿瘤，占所有原发性脑肿瘤的30%，所有恶性脑肿瘤的80%，以及脑肿瘤导致的绝大多数死亡病例。其中，多形性胶质母细胞瘤的病程最具侵袭性和浸润性。由于其异质性，治疗困难，而胶质瘤干细胞（GSCs）是其中一个原因。放疗和化疗等疗法用于治疗神经胶质瘤，但并未带来预期效果。因此，针对胶质瘤干细胞的治疗方法正在兴起。一种有前景的策略是用天然化合物靶向胶质瘤干细胞。本综述旨在描述胶质瘤干细胞问题、神经胶质瘤的治疗以及基于天然化合物的疗法，这些疗法对未来很有前景。
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