Yang Shu, Yang Shu, Xie Yuxiang, Duan Wenjing, Cui Yiting, Peng Ai, Zhou Yisheng, Fan Yibing, Li Hui, Huang Peng
Center for Evidence-Based Medicine, Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang 330019, China.
The Collaboration Unit for Field Epidemiology of State Key Laboratory of Infectious Disease Prevention and Control, Nanchang Center for Disease Control and Prevention, Nanchang 330038, China.
Trop Med Infect Dis. 2025 May 27;10(6):151. doi: 10.3390/tropicalmed10060151.
Scrub typhus is an acute febrile vector-borne infectious disease caused by () and transmitted through the bite of infected chigger mite larvae. Transmission involves complex ecological interactions among vectors, hosts, and environmental factors. Accumulating evidence indicates complex interactions between the scrub typhus incidence and multilevel environmental determinants, encompassing meteorological factors (e.g., temperature, humidity, precipitation, wind speed, sunshine duration, and atmospheric pressure), geographical conditions (e.g., topography, elevation, and landcover), and socioeconomic factors (e.g., economic level, cultural practices, residential conditions, and human behaviors). However, significant discrepancies persist among studies regarding the effect sizes and temporal associations, and the precise mechanisms remain incompletely elucidated. This review synthesizes the evidence on environment-disease relationships, clarifies the methodological inconsistencies, analyzes the potential sources of heterogeneity, and highlights the critical knowledge gaps to inform targeted prevention and control strategies and guide future research priorities.
恙虫病是由（）引起的急性发热性媒介传播传染病，通过感染的恙螨幼虫叮咬传播。传播涉及媒介、宿主和环境因素之间复杂的生态相互作用。越来越多的证据表明，恙虫病发病率与多层次环境决定因素之间存在复杂的相互作用，这些因素包括气象因素（如温度、湿度、降水、风速、日照时长和大气压力）、地理条件（如地形、海拔和土地覆盖）以及社会经济因素（如经济水平、文化习俗、居住条件和人类行为）。然而，关于效应大小和时间关联的研究之间仍存在显著差异，确切机制仍未完全阐明。本综述综合了环境与疾病关系的证据，阐明了方法上的不一致性，分析了异质性的潜在来源，并突出了关键的知识空白，以为有针对性的预防和控制策略提供信息并指导未来的研究重点。
