Fordyce Tiffani A, Leonhard Megan J, Jung Alesia M, Lin Jessica, Watson Heather, Heldt Gregory H, Boffetta Paolo
From the Health Sciences, Exponent, Inc., Menlo Park, CA (T.A.F., A.M.J.); Health Sciences, Exponent, Inc., Bellevue, Washington (M.J.L., J.L.); Data Sciences, Exponent, Inc., Bellevue, Washington (H.W.); Materion Brush, Inc., Elmore, OH (G.H.H.); and Stony Brook Cancer Center and Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York (P.B.).
J Occup Environ Med. 2025 Oct 1;67(10):e679-e689. doi: 10.1097/JOM.0000000000003463. Epub 2025 May 29.
Update and expand a cohort of beryllium workers, to examine risks associated with beryllium solubility and mortality from lung cancer, all cancers, all causes, as well as other neoplasms (kidney, bladder, central nervous system) and other nonmalignant respiratory disease.
The study conducted a retrospective cohort study of 17,149 workers employed in 15 US facilities (1925-2020). Data were analyzed using standardized mortality ratios referencing the US population and Cox models.
Lung cancer mortality was elevated among mixed beryllium (soluble and insoluble-exposed) workers hired pre-1955, but not among insoluble-only workers during any period. Other nonmalignant respiratory disease mortality was significantly elevated in the total cohort, driven by mortality among mixed-exposure facilities and among workers hired pre-1955.
No increase in lung cancer or other mortality for any timeframe for workers at insoluble-only beryllium facilities was observed.
更新并扩大铍作业工人队列，以研究与铍溶解性相关的风险以及肺癌、所有癌症、所有病因导致的死亡率，以及其他肿瘤（肾脏、膀胱、中枢神经系统）和其他非恶性呼吸道疾病。
该研究对美国15家工厂（1925 - 2020年）雇佣的17149名工人进行了回顾性队列研究。使用参照美国人群的标准化死亡比和Cox模型对数据进行分析。
1955年前雇佣的混合接触铍（可溶性和不溶性接触）工人的肺癌死亡率有所升高，但在任何时期仅接触不溶性铍的工人中未出现这种情况。在整个队列中，其他非恶性呼吸道疾病死亡率显著升高，这是由混合接触设施以及1955年前雇佣的工人的死亡率所驱动的。
未观察到仅接触不溶性铍设施的工人在任何时间段内肺癌或其他死亡率增加。
