高敏C反应蛋白升高的不稳定型心绞痛患者外周血单核细胞中训练免疫增强

Enhanced Trained Immunity in Peripheral Monocytes in Unstable Angina With Elevated High-Sensitivity C-Reactive Protein.

作者信息

Zhang Jiyu, Yang Fen, Liao Yuhan, Xia Xinyi, Yu Miao, Hu Desheng, Wang Weimin, Zhang Li, Wang Chaolong, Liu Huirong, Chen Chen, Wang Qing K, Shan Zhilei, Libby Peter, Cheng Xiang

机构信息

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, China.

Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

JACC Basic Transl Sci. 2025 Jun 24;10(7):101300. doi: 10.1016/j.jacbts.2025.04.014.

DOI:10.1016/j.jacbts.2025.04.014

PMID:40561640

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12256326/

Abstract

Despite effective secondary prevention for coronary heart diseases, recurrent events remain high. Elevated high-sensitivity C-reactive protein (hsCRP) indicates increased inflammation risk. This study aimed to investigate the trained immunity of circulating monocytes in unstable angina (UA) patients with elevated hsCRP. We analyzed CD14 monocytes from UA patients, comparing high-risk (hsCRP ≥3 mg/L) and low-risk (hsCRP <1 mg/L) groups. We assessed cytokine production and conducted metabolic, transcriptional, and epigenetic profiling. Patients with elevated hsCRP exhibited enhanced proinflammatory responses, glycolytic activity, and altered immune profiles, indicating sustained monocyte trained immunity, which contributes to residual inflammation risk in cardiovascular disease.

摘要

尽管针对冠心病有有效的二级预防措施，但复发事件的发生率仍然很高。高敏C反应蛋白（hsCRP）升高表明炎症风险增加。本研究旨在调查hsCRP升高的不稳定型心绞痛（UA）患者循环单核细胞的训练免疫情况。我们分析了UA患者的CD14单核细胞，比较了高危组（hsCRP≥3mg/L）和低危组（hsCRP<1mg/L）。我们评估了细胞因子的产生，并进行了代谢、转录和表观遗传分析。hsCRP升高的患者表现出增强的促炎反应、糖酵解活性和改变的免疫谱，表明单核细胞训练免疫持续存在，这导致了心血管疾病中的残余炎症风险。