Mourad Raja, Diab Ahmad, Merhi Zaher, Khalil Mohammad, Le Bouquin Jeannès Régine
Univ Rennes, Inserm, LTSI - UMR 1099, F-35000 Rennes, France; Signal Processing, Computer Hardware, Signals and Control Systems, Lebanese International University LIU, Tripoli, Lebanon; Signal Processing, Computer Hardware, Signals and Control Systems, International University of Beirut BIU, Beirut, Lebanon.
Signal Processing, Computer Hardware, Signals and Control Systems, Lebanese International University LIU, Tripoli, Lebanon; Signal Processing, Computer Hardware, Signals and Control Systems, International University of Beirut BIU, Beirut, Lebanon.
Brain Res. 2025 Oct 1;1864:149797. doi: 10.1016/j.brainres.2025.149797. Epub 2025 Jun 23.
Epilepsy is a neurological disorder affecting millions worldwide, characterized by recurrent and unpredictable seizures. Electroencephalography (EEG) is a widely used tool for seizure diagnosis, but the complexity and variability of EEG signals make manual analysis challenging. Machine Learning (ML) and Deep Learning (DL) techniques have emerged as powerful methods for automated Epileptic Seizure (ES) detection, classification, and prediction. However, questions remain regarding their effectiveness, interpretability, and clinical applicability. This systematic review critically examines ML and DL approaches applied to EEG-based seizure recognition, highlighting key challenges such as feature extraction, dataset selection, and model generalization. We analyze peer-reviewed studies from 2013 to 2023, sourced from the PubMed database, to compare various methodologies and evaluate their performance. Unlike prior reviews that focus on a single aspect of seizure recognition, this work provides a comprehensive overview of detection, classification, and prediction tasks. We also discuss the strengths and limitations of different ML and DL models, emphasizing the trade-offs between computational complexity, accuracy, and real-world implementation. Furthermore, this study outlines emerging trends, including the integration of explainable AI, transfer learning, and privacy-preserving techniques such as federated learning. By synthesizing the latest advancements, this review serves as a guide for researchers and clinicians seeking to enhance the reliability and efficiency of seizure recognition systems. Our findings aim to bridge the gap between AI-driven methodologies and clinical applications, paving the way for more robust and interpretable ES detection frameworks.
癫痫是一种影响全球数百万人的神经系统疾病,其特征是反复发作且不可预测的癫痫发作。脑电图(EEG)是癫痫发作诊断中广泛使用的工具,但EEG信号的复杂性和变异性使得人工分析具有挑战性。机器学习(ML)和深度学习(DL)技术已成为自动检测、分类和预测癫痫发作(ES)的强大方法。然而,关于它们的有效性、可解释性和临床适用性仍然存在问题。本系统综述批判性地审视了应用于基于EEG的癫痫发作识别的ML和DL方法,突出了诸如特征提取、数据集选择和模型泛化等关键挑战。我们分析了2013年至2023年来自PubMed数据库的同行评审研究,以比较各种方法并评估它们的性能。与以往专注于癫痫发作识别单一方面的综述不同,这项工作全面概述了检测、分类和预测任务。我们还讨论了不同ML和DL模型的优点和局限性,强调了计算复杂性、准确性和实际应用之间的权衡。此外,本研究概述了新兴趋势,包括可解释人工智能、迁移学习以及联邦学习等隐私保护技术的整合。通过综合最新进展,本综述为寻求提高癫痫发作识别系统可靠性和效率的研究人员和临床医生提供了指导。我们的研究结果旨在弥合人工智能驱动的方法与临床应用之间的差距,为更强大且可解释的ES检测框架铺平道路。