Kehl H, Fountain K, Early T
Arzneimittelforschung. 1978;28(11):2087-92.
A series of beta-hydroxylamine-phenylpropyl hydroxamic acids were prepared. The ability of these compounds to act as hypotensive agents was studied pharmacodynamically. Key structural features for the hypotensive action were identified and correlated to the degree of responses observed. It was ascertained that these compounds do not act through the adrenergic, cholinergic and histaminergic receptor system, but can be classified as direct acting vasodilators.
制备了一系列β-羟胺基-苯丙基异羟肟酸。对这些化合物作为降压剂的作用能力进行了药效学研究。确定了降压作用的关键结构特征，并将其与观察到的反应程度相关联。已确定这些化合物并非通过肾上腺素能、胆碱能和组胺能受体系统起作用，而是可归类为直接作用的血管扩张剂。
