Nashat K H, Slater D N, Underwood J C, Triger D R, Woods H F
J Hepatol. 1985;1(2):153-66. doi: 10.1016/s0168-8278(85)80763-7.
An experimental model for measuring the phagocytic function of the isolated perfused rat liver is described. A progressive rise in phagocytosis was observed with increasing liver blood flow. This is due to an increase in total particle uptake by the liver with no alteration in the rate constant for phagocytosis except at the highest flow rate. Phagocytosis is substantially greater in the livers of 100-day-old rats than in 21-day-old rats, but the number of particles ingested per unit weight by the older rats is significantly less. Liver phagocytosis is shown to be both temperature- and oxygen-dependent, but independent of nutritional status and animal gender. This model may be useful for assessing the effects of drugs and toxins on hepatic phagocytosis.
描述了一种用于测量离体灌注大鼠肝脏吞噬功能的实验模型。随着肝脏血流增加，观察到吞噬作用逐渐增强。这是由于肝脏对颗粒的总摄取量增加，除了在最高流速下，吞噬作用的速率常数没有改变。100日龄大鼠肝脏的吞噬作用明显大于21日龄大鼠，但老龄大鼠每单位重量摄取的颗粒数量明显较少。肝脏吞噬作用显示出对温度和氧气都有依赖性，但与营养状况和动物性别无关。该模型可能有助于评估药物和毒素对肝脏吞噬作用的影响。
