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癌症治疗中的生物纳米载体:精准给药的前沿创新

Biological Nanocarriers in Cancer Therapy: Cutting Edge Innovations in Precision Drug Delivery.

作者信息

Ganpisetti Ramesh, Giridharan Sanjay, Vaskuri G S Sainaga Jyothi, Narang Nikesh, Basim Pratap, Dokmeci Mehmet Remzi, Ermis Menekse, Rojekar Satish, Gholap Amol D, Kommineni Nagavendra

机构信息

Terasaki Institute of Biomedical Sciences, 21100 Erwin St, Woodland Hills, Los Angeles, CA 91367-3712, USA.

Arizona State University, 1151 S. Forest AV Tempe, Tempe, AZ 85281, USA.

出版信息

Biomolecules. 2025 May 31;15(6):802. doi: 10.3390/biom15060802.


DOI:10.3390/biom15060802
PMID:40563442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12191216/
Abstract

Cancer is a highly detrimental and fatal illness that poses a significant threat to human well-being. The pattern of cancer treatment is continuously being optimized by the advancement of old treatment approaches and the invention of novel treatment modes. Nanotechnology-based approaches are emerging as powerful candidates in the development of these advanced methods for treating tumors. This article provides a concise overview of nanotechnology for cancer or cancer nanomedicine and its applications. In light of prevalent issues, such as inadequate precision in targeting initial chemotherapy drugs, susceptibility of nucleic acid drugs to degradation, gene delivery, and the occurrence of common immune-related adverse events during immunotherapy, we explore the potential integration of nanomedicine with these treatment approaches and illustrative examples and highlight the benefits that arise from the utilization of nanomedicine.

摘要

癌症是一种极具危害性和致命性的疾病,对人类健康构成重大威胁。随着传统治疗方法的进步和新型治疗模式的发明,癌症治疗模式在不断优化。基于纳米技术的方法正成为开发这些先进肿瘤治疗方法的有力候选者。本文简要概述了用于癌症治疗的纳米技术或癌症纳米医学及其应用。鉴于一些普遍存在的问题,如初始化疗药物靶向精准度不足、核酸药物易降解、基因递送以及免疫治疗期间常见免疫相关不良事件的发生等,我们探讨了纳米医学与这些治疗方法潜在的结合方式及实例,并强调了利用纳米医学所带来的益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/7621b854d889/biomolecules-15-00802-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/e7575e45377a/biomolecules-15-00802-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/0de91a7701be/biomolecules-15-00802-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/a68af7e3340a/biomolecules-15-00802-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/bbe705b4d280/biomolecules-15-00802-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/d514a2157013/biomolecules-15-00802-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/7621b854d889/biomolecules-15-00802-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/e7575e45377a/biomolecules-15-00802-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/0de91a7701be/biomolecules-15-00802-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/a68af7e3340a/biomolecules-15-00802-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/bbe705b4d280/biomolecules-15-00802-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/d514a2157013/biomolecules-15-00802-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b9/12191216/7621b854d889/biomolecules-15-00802-g006.jpg

相似文献

[1]
Biological Nanocarriers in Cancer Therapy: Cutting Edge Innovations in Precision Drug Delivery.

Biomolecules. 2025-5-31

[2]
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[3]
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[4]
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[5]
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[6]
Hyaluronic acid-based drug nanocarriers as a novel drug delivery system for cancer chemotherapy: A systematic review.

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[7]
Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis.

Cochrane Database Syst Rev. 2021-11-16

[8]
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Eur J Cancer. 2007-1

[9]
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[10]
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引用本文的文献

[1]
Advanced Nanomaterials Functionalized with Metal Complexes for Cancer Therapy: From Drug Loading to Targeted Cellular Response.

Pharmaceuticals (Basel). 2025-7-3

本文引用的文献

[1]
DNA-Based Nanostructured Platforms as Drug Delivery Systems.

Chem Bio Eng. 2024-1-9

[2]
DNA origami-based composite nanosandwich for iteratively potentiated chemo-immunotherapy.

J Control Release. 2025-3-10

[3]
Therapeutic Antisense Oligonucleotides in Oncology: From Bench to Bedside.

Cancers (Basel). 2024-8-23

[4]
New Opportunities and Old Challenges in the Clinical translation of Nanotheranostics.

Nat Rev Mater. 2023-12

[5]
Nanocarriers of antigen proteins for vaccine delivery.

Int J Pharm. 2024-6-25

[6]
Lipid-based nanoparticles as drug delivery carriers for cancer therapy.

Front Oncol. 2024-4-10

[7]
A review of DNA nanoparticles-encapsulated drug/gene/protein for advanced controlled drug release: Current status and future perspective over emerging therapy approaches.

Int J Biol Macromol. 2024-5

[8]
DNA nanodevice as a multi-module co-delivery platform for combination cancer immunotherapy.

J Colloid Interface Sci. 2024-8

[9]
Nucleic acid-based drugs for patients with solid tumours.

Nat Rev Clin Oncol. 2024-6

[10]
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2024

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