Tsiquaye K, Zuckerman A
J Hepatol. 1985;1(6):663-9. doi: 10.1016/s0168-8278(85)80009-x.
Suramin, a polybasic anion, blocks the activity of the DNA polymerase encoded by the duck hepatitis B virus. The interaction with the virus was studied under conditions in which the property of the drug to bind with proteins was used with plasma obtained from infected ducks with viraemia. Inhibition of DNA polymerase activity associated with core particles from infected liver and circulating virions is irreversible, occurs in a dose-response fashion and suggests that inhibition results from suramin-virus interaction. The inhibition of the specific viral polymerase activity clearly indicates that this drug should be evaluated for the treatment of hepatitis B and infection caused by the related Hepadna viruses.
苏拉明是一种多价阴离子，可阻断鸭乙型肝炎病毒编码的DNA聚合酶的活性。在利用该药物与蛋白质结合特性的条件下，使用来自患有病毒血症的感染鸭的血浆研究了其与病毒的相互作用。与感染肝脏的核心颗粒和循环病毒粒子相关的DNA聚合酶活性的抑制是不可逆的，呈剂量反应方式，这表明抑制是由苏拉明与病毒的相互作用引起的。对特定病毒聚合酶活性的抑制清楚地表明，该药物应进行评估，以用于治疗乙型肝炎和由相关嗜肝DNA病毒引起的感染。
