Sponenberg D P, Bowling A T
J Hered. 1985 Sep-Oct;76(5):393-4.
A syndrome of multiple defects including cleft palate, polydactyly, and often syndactyly, shortened tibia-fibula, brachygnathism and scoliosis lethal to males is described in a family of Australian shepherd dogs. Female pups lack the cleft palate and survive, but may exhibit the other defects to a lesser degree than do males. Litter data suggest that the trait is inherited as an X-linked lethal gene, but the possibility of a sex-influenced autosomal allele cannot be ruled out. The syndrome may have arisen in conjunction with instability of the merle locus.
在一个澳大利亚牧羊犬家族中，描述了一种包括腭裂、多指（趾）畸形且常伴有并指（趾）畸形、胫腓骨缩短、短颌畸形和脊柱侧凸的多缺陷综合征，该综合征对雄性犬是致死性的。雌性幼犬没有腭裂且能存活，但可能会比雄性幼犬在较轻程度上表现出其他缺陷。窝产数据表明，该性状作为一种X连锁致死基因遗传，但不能排除受性别影响的常染色体等位基因的可能性。该综合征可能与貂色基因座的不稳定性有关。
