Wu Mengyan, Zeng Xingdong, Cai Yongle, Chen Haonan, Yang Hao
Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China.
Biomedicines. 2025 Jun 11;13(6):1436. doi: 10.3390/biomedicines13061436.
Thyroid hormone (TH) deficiency during the pregnancy and lactation periods leads to enduring memory impairments in offspring. However, the mechanisms underlying the cognitive and memory deficits induced by developmental hypothyroidism remain largely unexplored. Mice were exposed to propylthiouracil (PTU) or purified water to detect changes in hippocampal neurogenesis and differentiation of their offspring to explain the pathogenesis of impaired learning and memory. In addition, HT22 cell line were used to investigate the regulation between Maf and . Our findings indicate that developmental exposure to PTU results in abnormalities of the preferential differentiation of GABAergic interneurons and a subsequent reduction in PV inhibitory interneurons in the hippocampus of mouse pups. More significantly, we also indicate that the downregulation of Maf and the consequent alteration of are likely responsible for the mechanisms through which developmental hypothyroidism influences the differentiation and development of PV inhibitory interneurons in offspring. Consequently, the aberrant development of PV interneuron in the hippocampus of mice subjected to developmental hypothyroidism potentially contributes to memory deficits during adolescence and adulthood.
孕期和哺乳期甲状腺激素（TH）缺乏会导致后代出现持久性记忆障碍。然而，发育性甲状腺功能减退所致认知和记忆缺陷的潜在机制在很大程度上仍未得到探索。将小鼠暴露于丙硫氧嘧啶（PTU）或纯净水中，以检测其后代海马神经发生和分化的变化，从而解释学习和记忆受损的发病机制。此外，使用HT22细胞系研究Maf与……之间的调控。我们的研究结果表明，发育过程中暴露于PTU会导致幼鼠海马中GABA能中间神经元优先分化异常，随后PV抑制性中间神经元减少。更重要的是，我们还表明，Maf的下调以及随之而来的……改变可能是发育性甲状腺功能减退影响后代PV抑制性中间神经元分化和发育的机制。因此，发育性甲状腺功能减退小鼠海马中PV中间神经元的异常发育可能导致青春期和成年期的记忆缺陷。
